Cells of the vascular wall are exquisitely sensitive to changes in their mechanical
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …

One of the most remarkable differences between classical engineering materials and living
matter is the ability of the latter to grow and remodel in response to diverse stimuli. The …

The past two decades reveal a growing role of continuum biomechanics in understanding
homeostasis, adaptation, and disease progression in soft tissues. In this paper, we briefly …

Most mathematical models of the growth and remodeling of load-bearing soft tissues are
based on one of two major approaches: a kinematic theory that specifies an evolution …

Soft biological tissues compromise diverse cell types and extracellular matrix constituents,
each of which can possess individual natural configurations, material properties, and rates …

Cell signalling and mechanics influence vascular pathophysiology and there is an
increasing demand for in vitro model systems that enable examination of signalling between …

There is substantial evidence that growth and remodeling of load bearing soft biological
tissues is to a large extent controlled by mechanical factors. Mechanical homeostasis, which …

Background Tissue-engineered vascular grafts (TEVGs) have the potential to advance the
surgical management of infants and children requiring congenital heart surgery by creating …

Constrained mixture models for soft tissue growth and remodeling have attracted increasing
attention over the last decade. They can capture the effects of the simultaneous presence of …

The intermediate filament (IF) cytoskeleton has been proposed to regulate morphogenic
processes by integrating the cell fate signaling machinery with mechanical cues. Signaling …