Role of leptin in inflammation and vice versa
Inflammation is an essential immune response for the maintenance of tissue homeostasis. In
a general sense, acute and chronic inflammation are different types of adaptive response …
a general sense, acute and chronic inflammation are different types of adaptive response …
Leptin: A heavyweight player in obesity-related cancers
A Caruso, L Gelsomino, S Panza, FM Accattatis… - Biomolecules, 2023 - mdpi.com
Obesity, defined as the abnormal or excessive expansion of white adipose tissue, has
reached pandemic proportions and is recognized as an important health concern since it is …
reached pandemic proportions and is recognized as an important health concern since it is …
The role of selected adipocytokines in ovarian cancer and endometrial cancer
Due to their multidirectional influence, adipocytokines are currently the subject of numerous
intensive studies. Significant impact applies to many processes, both physiological and …
intensive studies. Significant impact applies to many processes, both physiological and …
The potential role of leptin in tumor invasion and metastasis
A Ray, MP Cleary - Cytokine & growth factor reviews, 2017 - Elsevier
The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in
obesity compared to its functions in the normal healthy state. In obese individuals, elevated …
obesity compared to its functions in the normal healthy state. In obese individuals, elevated …
[HTML][HTML] Explainable discovery of disease biomarkers: The case of ovarian cancer to illustrate the best practice in machine learning and Shapley analysis
Objective: Ovarian cancer is a significant health issue with lasting impacts on the community.
Despite recent advances in surgical, chemotherapeutic and radiotherapeutic interventions …
Despite recent advances in surgical, chemotherapeutic and radiotherapeutic interventions …
[HTML][HTML] Patient inflammatory status and CD4+/CD8+ intraepithelial tumor lymphocyte infiltration are predictors of outcomes in high-grade serous ovarian cancer
MP Pinto, C Balmaceda, ML Bravo, S Kato… - Gynecologic …, 2018 - Elsevier
Background High-grade serous ovarian cancer (HGSOC) is the most prevalent and
aggressive histologic type of ovarian cancer. To date, there are no reliable biomarkers to …
aggressive histologic type of ovarian cancer. To date, there are no reliable biomarkers to …
[HTML][HTML] New aspects of corpus luteum regulation in physiological and pathological conditions: involvement of adipokines and neuropeptides
E Mlyczyńska, M Kieżun, P Kurowska, M Dawid, K Pich… - Cells, 2022 - mdpi.com
The corpus luteum is a small gland of great importance because its proper functioning
determines not only the appropriate course of the estrous/menstrual cycle and embryo …
determines not only the appropriate course of the estrous/menstrual cycle and embryo …
Emerging concepts linking obesity with the hallmarks of cancer
There is compelling epidemiological evidence linking obesity to many tumours; however, the
molecular mechanisms fuelling this association are not clearly understood. Emerging …
molecular mechanisms fuelling this association are not clearly understood. Emerging …
Leptin-induced signaling pathways in cancer cell migration and invasion
Background Increasing evidence indicates that obesity is associated with tumor
development and progression. Leptin is an adipocyte-related hormone with a key role in …
development and progression. Leptin is an adipocyte-related hormone with a key role in …
Perirenal adipose tissue—current knowledge and future opportunities
The perirenal adipose tissue (PRAT), a component of visceral adipose tissue, has been
recently recognized as an important factor that contributes to the maintenance of the …
recently recognized as an important factor that contributes to the maintenance of the …