The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …

The N-methyl-d-aspartate (NMDA) receptor is an example of a heteromeric ligand-gated ion
channel that interacts with multiple intracellular proteins by way of different subunits. NMDA …

Context There are no studies of the natural history of major depressive disorder that lack
prevalence and clinic biases. Objectives To estimate risk factors for first lifetime onset and …

Abstract Thrombospondin-1 (TSP-1) is a naturally occurring inhibitor of angiogenesis that
limits vessel density in normal tissues and curtails tumor growth. Here, we show that the …

The N-methyl-d-aspartate (NMDA) receptors play critical roles in synaptic plasticity, neuronal
development, and excitotoxicity. Tyrosine phosphorylation of NMDA receptors by Src-family …

In mammals, neurons are highly differentiated and play distinctive functions even in the
same brain region. We found a novel cadherin-related neuronal receptor (Cnr) gene family …

Alcohol acts on numerous cellular and molecular targets to regulate neuronal
communication within the brain. Chronic alcohol exposure and acute withdrawal generate …

Upon exposure to ethanol, Drosophila display behaviors that are similar to ethanol
intoxication in rodents and humans. Using an inebriometer to measure ethanol-induced loss …

Fyn, a member of the Src-family protein-tyrosine kinase (PTK), is implicated in learning and
memory that involves N-methyl-d-aspartate (NMDA) receptor function. In this study, we …

N-Methyl-d-aspartate (NMDA) receptor channels play important roles in various
physiological functions such as synaptic plasticity and synapse formation underlying …