The brain is a highly energy-demanding organ and requires bioenergetic adaptability to
balance normal activity with pathophysiological fuelling of spontaneous recurrent seizures …

Mitochondria are highly plastic and dynamic organelles that have graded responses to the
changing cellular, environmental, and developmental cues. Mitochondria undergo constant …

Pyroptosis provides a new direction and broad prospects for cancer immunotherapy.
However, the development of a nanoplatform as a pyroptosis inducer is limited, and the …

Subcellular organelle‐targeted nanoformulations for cancer theranostics are receiving
increasing attention owing to their benefits of precise drug delivery, maximized therapeutic …

Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …

Immune checkpoint blockers (ICBs) have been applied for cancer therapy and achieved
great success in the field of cancer immunotherapy. Nevertheless, the broad application of …

Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disease caused by the
loss of dystrophin. DMD is associated with muscle degeneration, necrosis, inflammation …

Parkinson's disease (PD) is the second most common neurodegenerative disease and is
characterized by dopaminergic neuronal loss. The exact pathogenesis of PD is complex and …

CD8+ T cells play a central role in anti-tumor immunity. Naïve CD8+ T cells are active upon
tumor antigen stimulation, and then differentiate into functional cells and migrate towards the …

Abstract Calcium (Ca 2+) signaling is critical for cell function and cell survival. Mitochondria
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …