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Transcriptional architecture of the mammalian circadian clock
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …
behavioural processes in organisms. These cell-autonomous clocks are composed of a …
Formation of chromatin subcompartments by phase separation
Chromatin is partitioned on multiple length scales into subcompartments that differ from
each other with respect to their molecular composition and biological function. It is a key …
each other with respect to their molecular composition and biological function. It is a key …
Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization
The molecular mechanisms underlying folding of mammalian chromosomes remain poorly
understood. The transcription factor CTCF is a candidate regulator of chromosomal …
understood. The transcription factor CTCF is a candidate regulator of chromosomal …
3D structures of individual mammalian genomes studied by single-cell Hi-C
The folding of genomic DNA from the beads-on-a-string-like structure of nucleosomes into
higher-order assemblies is crucially linked to nuclear processes. Here we calculate 3D …
higher-order assemblies is crucially linked to nuclear processes. Here we calculate 3D …
Liquid–liquid phase separation in chromatin
In eukaryotic cells, protein and RNA factors involved in genome activities like transcription,
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …
Polyploidy, the nucleotype, and novelty: the impact of genome doubling on the biology of the cell
Polyploidy is a key mechanism of genome evolution and speciation, particularly in plants.
Many aspects of polyploidy have been elucidated with the tools that have become available …
Many aspects of polyploidy have been elucidated with the tools that have become available …
[HTML][HTML] Navigating challenges and opportunities in multi-omics integration for personalized healthcare
The field of multi-omics has witnessed unprecedented growth, converging multiple scientific
disciplines and technological advances. This surge is evidenced by a more than doubling in …
disciplines and technological advances. This surge is evidenced by a more than doubling in …
Transcription organizes euchromatin via microphase separation
In eukaryotes, DNA is packed inside the cell nucleus in the form of chromatin, which consists
of DNA, proteins such as histones, and RNA. Euchromatin, which is permissive for …
of DNA, proteins such as histones, and RNA. Euchromatin, which is permissive for …
Super-resolution microscopy with single molecules in biology and beyond–essentials, current trends, and future challenges
Single-molecule super-resolution microscopy has developed from a specialized technique
into one of the most versatile and powerful imaging methods of the nanoscale over the past …
into one of the most versatile and powerful imaging methods of the nanoscale over the past …
[HTML][HTML] The physics of active polymers and filaments
Active matter agents consume internal energy or extract energy from the environment for
locomotion and force generation. Already, rather generic models, such as ensembles of …
locomotion and force generation. Already, rather generic models, such as ensembles of …