Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …

Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

The primary cilium has recently stepped into the spotlight, as a flood of data show that this
organelle has crucial roles in vertebrate development and human genetic diseases. Cilia …

The extracellular antagonists of the Wnt signalling pathway can be divided into two broad
classes. Both classes of molecule prevent ligand-receptor interactions, but by different …

The Wnt signalling pathway is an ancient system that has been highly conserved during
evolution. It has a crucial role in the embryonic development of all animal species, in the …

Background Myeloma cells may secrete factors that affect the function of osteoblasts,
osteoclasts, or both. Methods We subjected purified plasma cells from the bone marrow of …

Wnt signaling through the canonical β-catenin pathway plays essential roles in development
and disease. L ow-density-lipoprotein receptor-r elated p roteins 5 and 6 (Lrp5 and Lrp6) in …

Background—Cardiomyocytes derived from human embryonic stem (hES) cells could be
useful in restoring heart function after myocardial infarction or in heart failure. Here, we …

Hair follicle morphogenesis is initiated by a dermal signal that induces the development of
placodes in the overlying epithelium. To determine whether WNT signals are required for …

Signaling by the Wnt family of secreted glycoproteins plays important roles in embryonic
development and adult homeostasis. Wnt signaling is modulated by a number of …