Physicochemical stability of monoclonal antibodies: a review
Y Le Basle, P Chennell, N Tokhadze, A Astier… - Journal of …, 2020 - Elsevier
Monoclonal antibodies (mAbs) are subject to instability issues linked to their protein nature.
In this work, we review the different mechanisms that can be linked to monoclonal antibodies …
In this work, we review the different mechanisms that can be linked to monoclonal antibodies …
Auristatin antibody drug conjugate physical instability and the role of drug payload
YT Adem, KA Schwarz, E Duenas… - Bioconjugate …, 2014 - ACS Publications
The conjugation of hydrophobic cytotoxic agents such as monomethyl auristatin E (MMAE)
to the interchain sulfhydryl groups of monoclonal antibodies (Mabs) through a protease …
to the interchain sulfhydryl groups of monoclonal antibodies (Mabs) through a protease …
Small amine molecules: solvent design toward facile improvement of protein stability against aggregation and inactivation
Proteins are prone to inactivation in aqueous solutions because chemical modification and
aggregation usually occur, particularly at high temperature. This review focuses on the …
aggregation usually occur, particularly at high temperature. This review focuses on the …
Enhancing protein stability under stress: osmolyte-based deep eutectic solvents as a biocompatible and robust stabilizing medium for lysozyme under heat and cold …
A Damjanović, M Logarušić, LM Tumir… - Physical Chemistry …, 2024 - pubs.rsc.org
In biomedical and biotechnological domains, liquid protein formulations are vital tools,
offering versatility across various fields. However, maintaining protein stability in a liquid …
offering versatility across various fields. However, maintaining protein stability in a liquid …
Agarose native gel electrophoresis analysis of thermal aggregation controlled by Hofmeister series
The effects of salting-in and salting-out salts defined by Hofmeister series on the solution
state of bovine serum albumin (BSA) in 50 mM Tris-HCl buffer at pH 7.4 before and after …
state of bovine serum albumin (BSA) in 50 mM Tris-HCl buffer at pH 7.4 before and after …
Thermodynamic and fluorescence analyses to determine mechanisms of IgG1 stabilization and destabilization by arginine
M Fukuda, D Kameoka, T Torizawa, S Saitoh… - Pharmaceutical …, 2014 - Springer
Purpose To investigate mechanisms governing the stabilization and destabilization of
immunoglobulin (IgG1) by arginine (Arg). Methods The effects of Arg on the aggregation …
immunoglobulin (IgG1) by arginine (Arg). Methods The effects of Arg on the aggregation …
Protein-associated cation clusters in aqueous arginine solutions and their effects on protein stability and size
V Vagenende, AX Han, M Mueller… - ACS chemical biology, 2013 - ACS Publications
Arginine is one of the most prominent residues in protein interactions, and arginine
hydrochloride is widely used as an additive in protein solutions because of its exceptional …
hydrochloride is widely used as an additive in protein solutions because of its exceptional …
Inhibition of protein aggregation by zwitterionic polymer-based core-shell nanogels
Protein aggregation is a process by which misfolded proteins polymerizes into aggregates
and forms fibrous structures with a β-sheet conformation, known as amyloids. It is an …
and forms fibrous structures with a β-sheet conformation, known as amyloids. It is an …
Arginine prevents thermal aggregation of hen egg white proteins
The control of aggregation and solubilization of hen egg white protein (HEWP) is an
important issue for industrial applications of one of the most familiar food protein sources …
important issue for industrial applications of one of the most familiar food protein sources …
Arginine to lysine mutations increase the aggregation stability of a single-chain variable fragment through unfolded-state interactions
JI Austerberry, A Thistlethwaite, K Fisher… - Biochemistry, 2019 - ACS Publications
Increased protein solubility is known to correlate with an increase in the proportion of lysine
over arginine residues. Previous work has shown that the aggregation propensity of a single …
over arginine residues. Previous work has shown that the aggregation propensity of a single …