Inflammation and fibrosis in murine models of heart failure

L Bacmeister, M Schwarzl, S Warnke, B Stoffers… - Basic research in …, 2019 - Springer
Heart failure is a consequence of various cardiovascular diseases and associated with poor
prognosis. Despite progress in the treatment of heart failure in the past decades, prevalence …

Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases

D Liu, X Zeng, X Li, JL Mehta, X Wang - Basic research in cardiology, 2018 - Springer
NLRP3 inflammasome is a key multiprotein signaling platform that tightly controls
inflammatory responses and coordinates antimicrobial host defenses by activating caspase …

[HTML][HTML] Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: the role of the ERK-CREB pathway and Bnip3-mediated mitophagy

R Li, T ** macrophage polarization over the myocardial infarction time continuum
AJ Mouton, KY DeLeon-Pennell… - Basic research in …, 2018 - Springer
In response to myocardial infarction (MI), cardiac macrophages regulate inflammation and
scar formation. We hypothesized that macrophages undergo polarization state changes over …

ER–mitochondria microdomains in cardiac ischemia–reperfusion injury: a fresh perspective

H Zhou, S Wang, S Hu, Y Chen, J Ren - Frontiers in Physiology, 2018 - frontiersin.org
The mitochondrial and endoplasmic reticulum (ER) homeostasis is pivotal to the
maintenance of an array of physiological processes. The physical contact and association …

A sequential sustained-release hydrogel with potent antimicrobial, anti-inflammatory, and osteogenesis-promoting properties for the treatment of periodontitis

F Xu, T Deng, W Li, Y Ai, J Wu, Y Yang, C He… - Chemical Engineering …, 2023 - Elsevier
Periodontitis is a pathological disorder characterized by inflammation and tissue destruction;
it is primarily attributed to bacterial infection and immune responses. Nevertheless, existing …

LXR/RXR signaling and neutrophil phenotype following myocardial infarction classify sex differences in remodeling

KY DeLeon-Pennell, AJ Mouton, OK Ero, Y Ma… - Basic research in …, 2018 - Springer
Sex differences in heart failure development following myocardial infarction (MI) are not fully
understood. We hypothesized that differential MI signaling could explain variations in …

Macrophage-driven cardiac inflammation and healing: insights from homeostasis and myocardial infarction

W Zuo, R Sun, Z Ji, G Ma - Cellular & Molecular Biology Letters, 2023 - Springer
Early and prompt reperfusion therapy has markedly improved the survival rates among
patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling …

BI1 alleviates cardiac microvascular ischemia‐reperfusion injury via modifying mitochondrial fission and inhibiting XO/ROS/F‐actin pathways

H Zhou, J Wang, S Hu, H Zhu, S Toan… - Journal of cellular …, 2019 - Wiley Online Library
Pathogenesis of cardiac microvascular ischemia‐reperfusion (IR) injury is associated with
excessive mitochondrial fission. However, the upstream mediator of mitochondrial fission …

Sema3A drives alternative macrophage activation in the resolution of periodontitis via PI3K/AKT/mTOR signaling

T Tian, L Chen, Z Wang, M Zhu, W Xu, B Wu - Inflammation, 2023 - Springer
Macrophages actively participate in immunomodulatory processes throughout periodontal
inflammation. Regulation of M1/M2 polarization affects macrophage chemokine and …