In the last 10 years, mortality from acute myocardial infarction (AMI) has not significantly
decreased. This situation is associated with the absence in clinical practice of highly …

Necroptosis, a genetically programmed form of necrotic cell death, serves as an important
pathway in human diseases. As a critical cell-killing mechanism, necroptosis is associated …

The redox state is essential to the process of cell life, which determines cell fate. As an
important signaling molecule of the redox state, reactive oxygen species (ROS) are crucial …

Regulated cell death modalities such as apoptosis and necroptosis play an important role in
regulating different cellular processes. Currently, regulated cell death is identified using the …

Background & aims Autoimmune hepatitis (AIH) is characterized by hepatocyte destruction,
leading to lymphocyte and macrophage accumulation in the liver. Macrophages are key …

Necroptosis is one of a regulated programmed death mode, fibrosis is closely related with
cell death. It has been reported that inhibition of necroptosis can play the protective role in …

Cadmium (Cd) is a type of toxic substance, which widely exists in nature. However, the effect
of Cd exposure on the toxicity of swine lungs and its underlying mechanism involved have …

Taxanes, microtubule stabilizing agents, are extensively used in the treatment of non-small
cell lung cancer (NSCLC). However, their clinical effectiveness remains restricted owing to …

The prognosis for non-resectable or recurrent osteosarcoma (OS) remains poor. The finding
that the majority of OS overexpress the protooncogene HER2 raises the possibility of using …

Mortality from colorectal cancer (CRC) is significant, and novel CRC therapies are needed.
A pseudokinase MLKL typically executes necroptotic cell death, and MLKL inactivation …