Functional characterization of human pluripotent stem cell-derived models of the brain with microelectrode arrays

A Pelkonen, C Pistono, P Klecki, M Gómez-Budia… - Cells, 2021 - mdpi.com
Human pluripotent stem cell (hPSC)-derived neuron cultures have emerged as models of
electrical activity in the human brain. Microelectrode arrays (MEAs) measure changes in the …

[HTML][HTML] Neuromorphic-based neuroprostheses for brain rewiring: state-of-the-art and perspectives in neuroengineering

M Chiappalone, VR Cota, M Carè, M Di Florio… - Brain sciences, 2022 - mdpi.com
Neuroprostheses are neuroengineering devices that have an interface with the nervous
system and supplement or substitute functionality in people with disabilities. In the collective …

Loss of neuron network coherence induced by virus-infected astrocytes: a model study

SV Stasenko, AE Hramov, VB Kazantsev - Scientific Reports, 2023 - nature.com
Coherent activations of brain neuron networks underlie many physiological functions
associated with various behavioral states. These synchronous fluctuations in the electrical …

Design of Cultured Neuron Networks in vitro with Predefined Connectivity Using Asymmetric Microfluidic Channels

A Gladkov, Y Pigareva, D Kutyina, V Kolpakov… - Scientific reports, 2017 - nature.com
The architecture of neuron connectivity in brain networks is one of the basic mechanisms by
which to organize and sustain a particular function of the brain circuitry. There are areas of …

Impact of modular organization on dynamical richness in cortical networks

H Yamamoto, S Moriya, K Ide, T Hayakawa… - Science …, 2018 - science.org
As in many naturally formed networks, the brain exhibits an inherent modular architecture
that is the basis of its rich operability, robustness, and integration-segregation capacity …

Modular microstructure design to build neuronal networks of defined functional connectivity

C Forró, G Thompson-Steckel, S Weaver… - Biosensors and …, 2018 - Elsevier
Theoretical and in vivo neuroscience research suggests that functional information transfer
within neuronal networks is influenced by circuit architecture. Due to the dynamic …

On the road to the brain-on-a-chip: a review on strategies, methods, and applications

M Brofiga, M Pisano, R Raiteri… - Journal of Neural …, 2021 - iopscience.iop.org
The brain is the most complex organ of our body. Such a complexity spans from the single-
cell morphology up to the intricate connections that hundreds of thousands of neurons …

Electrophysiology read-out tools for brain-on-Chip biotechnology

C Forro, D Caron, GN Angotzi, V Gallo, L Berdondini… - Micromachines, 2021 - mdpi.com
Brain-on-Chip (BoC) biotechnology is emerging as a promising tool for biomedical and
pharmaceutical research applied to the neurosciences. At the convergence between lab-on …

Structure-function dynamics of engineered, modular neuronal networks with controllable afferent-efferent connectivity

N Winter-Hjelm, ÅB Tomren, P Sikorski… - Journal of Neural …, 2023 - iopscience.iop.org
Objective. Microfluidic devices interfaced with microelectrode arrays have in recent years
emerged as powerful platforms for studying and manipulating in vitro neuronal networks at …

A neuromorphic prosthesis to restore communication in neuronal networks

S Buccelli, Y Bornat, I Colombi, M Ambroise, L Martines… - IScience, 2019 - cell.com
Recent advances in bioelectronics and neural engineering allowed the development of
brain machine interfaces and neuroprostheses, capable of facilitating or recovering …