Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy
Interleukin-1 receptor-associated kinases (IRAK1, IRAK2, IRAK3 [IRAK-M], and IRAK4) are
serine-threonine kinases involved in toll-like receptor and interleukin-1 signaling pathways …
serine-threonine kinases involved in toll-like receptor and interleukin-1 signaling pathways …
The recent advance of Interleukin-1 receptor associated kinase 4 inhibitors for the treatment of inflammation and related diseases
YR Bai, WG Yang, XH Hou, DD Shen, SN Zhang… - European Journal of …, 2023 - Elsevier
The interleukin-1 receptor associated kinase 4 (IRAK-4) is a member of serine-threonine
kinase family, which plays an important role in the regulation of interleukin-1 receptors (IL …
kinase family, which plays an important role in the regulation of interleukin-1 receptors (IL …
IRAK signalling in cancer
Innate immune signalling has an essential role in inflammation, and the dysregulation of
signalling components of this pathway is increasingly being recognised as an important …
signalling components of this pathway is increasingly being recognised as an important …
IRAK-4 inhibitors for inflammation
Z Wang, H Wesche, T Stevens… - Current topics in …, 2009 - benthamdirect.com
Interleukin-1 receptor-associated kinases (IRAKs) are key components in the signal
transduction pathways utilized by interleukin-1 receptor (IL-1R), interleukin-18 receptor (IL …
transduction pathways utilized by interleukin-1 receptor (IL-1R), interleukin-18 receptor (IL …
Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and …
IRAK4, a serine/threonine kinase, plays a key role in both inflammation and oncology
diseases. Herein, we summarize the compelling biology surrounding the IRAK4 signaling …
diseases. Herein, we summarize the compelling biology surrounding the IRAK4 signaling …
Discovery of CA-4948, an orally bioavailable IRAK4 inhibitor for treatment of hematologic malignancies
VR Gummadi, A Boruah, BR Ainan… - ACS Medicinal …, 2020 - ACS Publications
Small molecule potent IRAK4 inhibitors from a novel bicyclic heterocycle class were
designed and synthesized based on hits identified from Aurigene's compound library. The …
designed and synthesized based on hits identified from Aurigene's compound library. The …
Endogenous ligands of TLR4 promote unresolving tissue fibrosis: Implications for systemic sclerosis and its targeted therapy
Fibrosis, the hallmark of scleroderma or systemic sclerosis (SSc), is a complex, dynamic and
generally irreversible pathophysiological process that leads to tissue disruption, and lacks …
generally irreversible pathophysiological process that leads to tissue disruption, and lacks …
Recent advances in IRAK1: pharmacological and therapeutic aspects
KM Kim, NH Hwang, JS Hyun, D Shin - Molecules, 2024 - mdpi.com
Interleukin receptor-associated kinase (IRAK) proteins are pivotal in interleukin-1 and Toll-
like receptor-mediated signaling pathways. They play essential roles in innate immunity and …
like receptor-mediated signaling pathways. They play essential roles in innate immunity and …
Crystal structure of human IRAK1
Interleukin 1 (IL-1) receptor-associated kinases (IRAKs) are serine/threonine kinases that
play critical roles in initiating innate immune responses against foreign pathogens and other …
play critical roles in initiating innate immune responses against foreign pathogens and other …
Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse …
Herein we report the optimization of a series of pyrrolopyrimidine inhibitors of interleukin-1
receptor associated kinase 4 (IRAK4) using X-ray crystal structures and structure based …
receptor associated kinase 4 (IRAK4) using X-ray crystal structures and structure based …