Osteoarthritis (OA) is a musculoskeletal disease characterized by progressive degeneration
of osteochondral tissues. Current treatment is restricted to the reduction of pain and loss of …

Cartilage is a connective tissue in the skeletal system and has limited regeneration ability
and unique biomechanical reactivity. The growth and development of cartilage can be …

Fumonisins are protein serine/threonine phosphatase inhibitors and potent inhibitors of
sphingosine N-acyltransferase (ceramide synthase) disrupting de novo sphingolipid …

Mechanobiology is a rapidly advancing field, with growing evidence that mechanical
signaling plays key roles in health and disease. To accelerate mechanobiology-based drug …

Glycosphingolipids (GSLs), a subtype of glycolipids containing sphingosine, are critical
components of vertebrate plasma membranes, playing a pivotal role in cellular signaling …

Introduction Growth plate damage in long bones often results in progressive skeletal growth
imbalance and deformity, leading to significant physical problems. Gangliosides, key …

Meniscus fibrochondrocytes (MFCs) are an important cell population responsible for
regulating the biomechanical properties of the knee meniscus. Despite their significance, not …

Glycosphingolipids (GSLs), a subtype of glycolipids containing sphingosine, are critical
components of vertebrate plasma membranes, playing a pivotal role in cellular signaling …

Menisci are fibrocartilaginous structures of the knee that function in mechanical load
transmission to protect articular cartilage from forces that may initiate osteoarthritic changes …