The chemical constituents and diverse pharmacological importance of Tinospora cordifolia

P Sharma, BP Dwivedee, D Bisht, AK Dash, D Kumar - Heliyon, 2019 - cell.com
Tinospora cordifolia is a popular medicinal plant which is used in several traditional
medicines to cure various diseases. The common names are Amrita and Guduchi and …

Flavonoids as promising neuroprotectants and their therapeutic potential against Alzheimer's disease

T Minocha, H Birla, AA Obaid, V Rai… - Oxidative Medicine …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is one of the serious and progressive neurodegenerative
disorders in the elderly worldwide. Various genetic, environmental, and lifestyle factors are …

Neuroprotective effect of chlorogenic acid on mitochondrial dysfunction‐mediated apoptotic death of DA neurons in a parkinsonian mouse model

SS Singh, SN Rai, H Birla, W Zahra… - Oxidative medicine …, 2020 - Wiley Online Library
Mitochondrial dysfunction and oxidative stress characterize major factors involved in the
activation of complex processes corresponding to apoptosis‐mediated neuronal …

NF-κB-mediated neuroinflammation in Parkinson's disease and potential therapeutic effect of polyphenols

SS Singh, SN Rai, H Birla, W Zahra, AS Rathore… - Neurotoxicity …, 2020 - Springer
Different animal and human studies from last two decades in the case of Parkinson's
disease (PD) have concentrated on oxidative stress due to increased inflammation and …

Advancement in the modelling and therapeutics of Parkinson's disease

SN Rai, P Singh - Journal of chemical neuroanatomy, 2020 - Elsevier
Since the discovery of L-dopa in the middle of the 20th century (1960s), there is not any
neuroprotective therapy available although significant development has been made in the …

Therapeutic potential of vital transcription factors in Alzheimer's and Parkinson's disease with particular emphasis on transcription factor EB mediated autophagy

SN Rai, N Tiwari, P Singh, D Mishra, AK Singh… - Frontiers in …, 2021 - frontiersin.org
Autophagy is an important cellular self-digestion and recycling pathway that helps in
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …

Metformin role in Parkinson's disease: a double-sword effect

M Alrouji, HM Al-Kuraishy, AI Al-Gareeb… - Molecular and Cellular …, 2024 - Springer
Parkinson's disease (PD) is a common neurodegenerative disease developed due to the
degeneration of dopaminergic neurons in the substantia nigra. There is no single effective …

Anti-inflammatory activity of ursolic acid in MPTP-induced parkinsonian mouse model

SN Rai, W Zahra, SS Singh, H Birla, C Keswani… - Neurotoxicity …, 2019 - Springer
Neuroinflammation plays an important role in the progression of Parkinson's disease (PD)
and hence may represent a target for treatment. The drugs used currently for PD only …

Exploring the role of nanomedicines for the therapeutic approach of central nervous system dysfunction: At a glance

MM Rhaman, MR Islam, S Akash, M Mim… - Frontiers in Cell and …, 2022 - frontiersin.org
In recent decades, research scientists, molecular biologists, and pharmacologists have
placed a strong emphasis on cutting-edge nanostructured materials technologies to …

Mucuna pruriens in Parkinson's and in some other diseases: recent advancement and future prospective

SN Rai, VK Chaturvedi, P Singh, BK Singh, MP Singh - 3 Biotech, 2020 - Springer
Mucuna pruriens (Mp) is an annual and perennial legume which belongs to the family
Fabaceae having different types of therapeutic activity. Anti-oxidative, anti-inflammatory, anti …