Losartan as an ACE inhibitor: a description of the mechanism of action through quantum biochemistry

EM Bezerra, ÉC de Alvarenga, RP Dos Santos… - RSC …, 2022 - pubs.rsc.org
Losartan (LST) is a potent and selective angiotensin II (Ang II) type 1 (AT1) receptor
antagonist widely used in the treatment of hypertension. The formation of Ang II is catalyzed …

The insertion of functional groups in organic selenium compounds promote changes in mitochondrial parameters and raise the antibacterial activity

ST Stefanello, CR Mizdal, DF Gonçalves… - Bioorganic …, 2020 - Elsevier
Organic selenium compounds are widely associated with numerous pharmacological
properties. However, selenium compounds, such as Ebselen (Ebs) and Diphenyl Diselenide …

The solubilization of diphenyl diselenide in surfactant solutions

K Pawar, RV Jayaram, SS Bhagwat - Journal of Dispersion …, 2023 - Taylor & Francis
Solubilization of diphenyl diselenide (DPDS) was studied in CTAB, OPE-10 and SDS
surfactant solutions at 298 K. Solubility of DPDS increases with increase in the surfactant …

The Se… S/N interactions as a possible mechanism of δ-aminolevulinic acid dehydratase enzyme inhibition by organoselenium compounds: A computational study

PA Nogara, L Orian, JBT Rocha - Computational Toxicology, 2020 - Elsevier
Organoselenium compounds present many pharmacological properties and are promising
drugs. However, toxicological effects associated with inhibition of thiol-containing enzymes …

Molecular docking analysis of acetylcholinesterase corroborates the protective effect of pralidoxime against chlorpyrifos-induced behavioral and neurochemical …

FDA da Silva, PA Nogara, MM Braga, BC Piccoli… - Computational …, 2018 - Elsevier
Toxic organophosphates (OPs) are widely used by the man to manage crops and household
insects. Here we used the cockroach, Nauphoeta cinerea, as an alternative model to study …