Unveiling microbial diversity: harnessing long-read sequencing technology

DP Agustinho, Y Fu, VK Menon, GA Metcalf… - Nature …, 2024 - nature.com
Long-read sequencing has recently transformed metagenomics, enhancing strain-level
pathogen characterization, enabling accurate and complete metagenome-assembled …

Unraveling metagenomics through long-read sequencing: A comprehensive review

C Kim, M Pongpanich, T Porntaveetus - Journal of Translational Medicine, 2024 - Springer
The study of microbial communities has undergone significant advancements, starting from
the initial use of 16S rRNA sequencing to the adoption of shotgun metagenomics. However …

Comparison of 6 DNA extraction methods for isolation of high yield of high molecular weight DNA suitable for shotgun metagenomics Nanopore sequencing to detect …

M Gand, B Bloemen, K Vanneste, NHC Roosens… - BMC genomics, 2023 - Springer
Abstract Background Oxford Nanopore Technologies (ONT) offers an accessible platform for
long-read sequencing, which improves the reconstruction of genomes and helps to resolve …

Finding the right fit: evaluation of short-read and long-read sequencing approaches to maximize the utility of clinical microbiome data

JL Gehrig, DM Portik, MD Driscoll… - Microbial …, 2022 - microbiologyresearch.org
A long-standing challenge in human microbiome research is achieving the taxonomic and
functional resolution needed to generate testable hypotheses about the gut microbiota's …

The application of metagenomics to study microbial communities and develop desirable traits in fermented foods

M Srinivas, O O'Sullivan, PD Cotter, D Sinderen… - Foods, 2022 - mdpi.com
The microbial communities present within fermented foods are diverse and dynamic,
producing a variety of metabolites responsible for the fermentation processes, imparting …

Comparative analysis of metagenomic classifiers for long-read sequencing datasets

J Marić, K Križanović, S Riondet, N Nagarajan… - BMC …, 2024 - Springer
Background Long reads have gained popularity in the analysis of metagenomics data.
Therefore, we comprehensively assessed metagenomics classification tools on the species …

Amplicon-based microbiome profiling: from second-to third-generation sequencing for higher taxonomic resolution

E Notario, G Visci, B Fosso, C Gissi, N Tanaskovic… - Genes, 2023 - mdpi.com
The 16S rRNA amplicon-based sequencing approach represents the most common and
cost-effective strategy with great potential for microbiome profiling. The use of second …

Refining sampling efforts for fish diversity assessment in subtropical urban estuarine and oceanic waters using environmental DNA with multiple primers

CM How, JCH Ip, D Deconinck, M Zhao… - Environmental …, 2024 - Wiley Online Library
The environmental DNA (eDNA) approach is an emerging tool for monitoring marine
biodiversity. However, the sampling effort needs optimization according to the site …

Analysis of metagenomic data

S Liu, JS Rodriguez, V Munteanu… - Nature Reviews …, 2025 - nature.com
Metagenomics has revolutionized our understanding of microbial communities, offering
unprecedented insights into their genetic and functional diversity across Earth's diverse …

Evaluating metagenomics and targeted approaches for diagnosis and surveillance of viruses

S Buddle, L Forrest, N Akinsuyi, LM Martin Bernal… - Genome Medicine, 2024 - Springer
Background Metagenomics is a powerful approach for the detection of unknown and novel
pathogens. Workflows based on Illumina short-read sequencing are becoming established …