There are declines with age in speed of processing, working memory, inhibitory function,
and long-term memory, as well as decreases in brain structure size and white matter …

During the past century, treatments for the diseases of youth and middle age have helped
raise life expectancy significantly. However, cognitive decline has emerged as one of the …

Brain aging research relies mostly on cross-sectional studies, which infer true changes from
age differences. We present longitudinal measures of five-year change in the regional brain …

In this review, we report on studies that have assessed the effects of exogenous and
endogenous increases in stress hormones on human cognitive performance. We first …

Memory decline in aging results from multiple factors that influence both executive function
and the medial temporal lobe memory system. In advanced aging, frontal-striatal systems …

What can be expected in normal aging, and where does normal aging stop and pathological
neurodegeneration begin? With the slow progression of age-related dementias such as …

The structure of the brain is constantly changing from birth throughout the lifetime, meaning
that normal aging, free from dementia, is associated with structural brain changes. This …

Deciphering the secret of successful aging depends on understanding the patterns and
biological underpinnings of cognitive and behavioral changes throughout adulthood. That …

The human brain changes with age. However, the rate and the trajectories of change vary
among the brain regions and among individuals, and the reasons for these differences are …

Cross-sectional magnetic resonance imaging (MRI) studies of cortical thickness and volume
have shown age effects on large areas, but there are substantial discrepancies across …