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APOL1 nephropathy: from genetics to clinical applications
Rates of many types of severe kidney disease are much higher in Black individuals than
most other ethnic groups. Much of this disparity can now be attributed to genetic variants in …
most other ethnic groups. Much of this disparity can now be attributed to genetic variants in …
Social determinants of racial disparities in CKD
JM Norton, MM Moxey-Mims, PW Eggers… - Journal of the …, 2016 - journals.lww.com
Significant disparities in CKD rates and outcomes exist between black and white Americans.
Health disparities are defined as health differences that adversely affect disadvantaged …
Health disparities are defined as health differences that adversely affect disadvantaged …
The key role of NLRP3 and STING in APOL1-associated podocytopathy
Coding variants in apolipoprotein L1 (APOL1), termed G1 and G2, can explain most excess
kidney disease risk in African Americans; however, the molecular pathways of APOL1 …
kidney disease risk in African Americans; however, the molecular pathways of APOL1 …
Evaluating the promise of inclusion of African ancestry populations in genomics
The lack of representation of diverse ancestral backgrounds in genomic research is well-
known, and the resultant scientific and ethical limitations are becoming increasingly …
known, and the resultant scientific and ethical limitations are becoming increasingly …
APOL1-associated nephropathy: a key contributor to racial disparities in CKD
Genetic methodologies are improving our understanding of the pathophysiology in diverse
diseases. Breakthroughs have been particularly impressive in nephrology, for which marked …
diseases. Breakthroughs have been particularly impressive in nephrology, for which marked …
[HTML][HTML] Sensitization in transplantation: assessment of risk (STAR) 2019 working group meeting report
The purpose of the STAR 2019 Working Group was to build on findings from the initial STAR
report to further clarify the expectations, limitations, perceptions, and utility of alloimmune …
report to further clarify the expectations, limitations, perceptions, and utility of alloimmune …
APOL1 genotype and kidney transplantation outcomes from deceased African American donors
Background Two apolipoprotein L1 gene (APOL1) renal-risk variants in donors and African
American (AA) recipient race are associated with worse allograft survival in deceased-donor …
American (AA) recipient race are associated with worse allograft survival in deceased-donor …
APOL1 genotype and renal function of black living donors
Black living kidney donors are at higher risk of develo** kidney disease than white
donors. We examined the effect of the APOL1 high-risk genotype on postdonation renal …
donors. We examined the effect of the APOL1 high-risk genotype on postdonation renal …
APOL1 renal-risk variants induce mitochondrial dysfunction
Abstract APOL1 G1 and G2 variants facilitate kidney disease in blacks. To elucidate the
pathways whereby these variants contribute to disease pathogenesis, we established …
pathways whereby these variants contribute to disease pathogenesis, we established …
[HTML][HTML] APOL1 long-term kidney transplantation outcomes network (APOLLO): design and rationale
BI Freedman, MM Moxey-Mims, AA Alexander… - Kidney international …, 2020 - Elsevier
Introduction Much of the higher risk for end-stage kidney disease (ESKD) in African
American individuals relates to ancestry-specific variation in the apolipoprotein L1 gene …
American individuals relates to ancestry-specific variation in the apolipoprotein L1 gene …