Alzheimer's disease is an irreversible, progressive neurodegenerative disorder. Various
therapeutic approaches are being used to improve the cholinergic neurotransmission, but …

Highlights•Which molecular dynamics (MD) techniques are available for drug design?•How
is MD used to investigate ligand–macromolecule complexes?•How are MD studies applied …

Zinc is present in a wide variety of proteins and is important in the metabolism of most
organisms. Zinc metalloenzymes are therapeutically relevant targets in diseases such as …

Kluyveromyces marxianus protein hydrolysates were prepared by two different sonicated-
enzymatic (trypsin and chymotrypsin) hydrolysis treatments to obtain antioxidant and ACE …

Alcalase, neutral protease, and pepsin were used to hydrolyze the skin of Takifugu flavidus.
The T. flavidus hydrolysates (TFHs) with the maximum degree of hydrolysis (DH) and …

The purpose of this study is to explore the effects of IVTNWDDMEK and VGPAGPRG, two
angiotensin I-converting enzyme (ACE) inhibitory peptides purified from Volutharpa …

Introduction: Midlife hypertension has been consistently linked with increased risk of
cognitive decline and Alzheimer's disease (AD). Observational studies and randomized …

The interaction between angiotensin I-converting enzyme (ACE) and the inhibitory peptide
KNFL from Wakame was explored using isothermal titration calorimetry, multiple …

This study aimed to identify angiotensin I-converting enzyme (ACE) from in vitro digestion
products of pork sausage with partial substitution of NaCl by KCl (PSRK). Peptides from in …

The rapid outbreak of SARS-Coronavirus 2 (SARS-CoV-2) caused a serious global public
health threat. The spike 'S'protein of SARS-CoV-2 and ACE2 of the host cell are being …