Accumulating evidence points to the causal role of triglyceride-rich lipoproteins and their
cholesterol-enriched remnants in atherogenesis. Genetic studies in particular have not only …

Highly potent, but poorly water-soluble, drug candidates are common outcomes of
contemporary drug discovery programmes and present a number of challenges to drug …

Our knowledge of the uptake and transport of dietary fat and fat-soluble vitamins has
advanced considerably. Researchers have identified several new mechanisms by which …

Recent data suggest that dietary fat promotes intestinal absorption of lipopolysaccharides
(LPS) from the gut microflora, which might contribute to various inflammatory disorders. The …

Vitamin A deficiency is a public health problem in most develo** countries, especially in
children and pregnant women. It is thus a priority in health policy to improve preformed …

Various secondary plant metabolites or phytochemicals, including polyphenols and
carotenoids, have been associated with a variety of health benefits, such as reduced …

Hyperlipidemia is a risk factor for various cardiovascular and metabolic disorders.
Overproduction of lipoproteins, a process that is dependent on microsomal triglyceride …

The development of obesity and insulin resistance has been extensively studied in the last
decades, but the mechanisms underlying these alterations are still not completely …

Plasma HDL cholesterol levels are inversely related to risk for atherosclerosis. The ATP-
binding cassette, subfamily A, member 1 (ABCA1) mediates the rate-controlling step in HDL …

Although statin therapy represents a cornerstone of cardiovascular disease (CVD)
prevention, a major residual CVD risk (60–70% of total relative risk) remains, attributable to …