Research frontiers of electroporation-based applications in cancer treatment: A bibliometric analysis

K Qian, Z Zhong - Biomedical Engineering/Biomedizinische Technik, 2023 - degruyter.com
Objectives Electroporation, the breakdown of the biomembrane induced by external electric
fields, has increasingly become a research hotspot for its promising related methods in …

First human trial of high-frequency irreversible electroporation therapy for prostate cancer

S Dong, H Wang, Y Zhao, Y Sun… - Technology in cancer …, 2018 - journals.sagepub.com
Irreversible electroporation, as a nonthermal therapy of prostate cancer, has been used in
clinic for several years. The mechanism of irreversible electroporation ablation is thermal …

Cancellation effect is present in high-frequency reversible and irreversible electroporation

T Polajžer, J Dermol–Černe, M Reberšek… - …, 2020 - Elsevier
It was recently suggested that applying high-frequency short biphasic pulses (HF-IRE)
reduces pain and muscle contractions in electrochemotherapy and irreversible ablation …

Experimental high-frequency irreversible electroporation using a single-needle delivery approach for nonthermal pancreatic ablation in vivo

TJ O'Brien, M Passeri, MF Lorenzo, JK Sulzer… - Journal of Vascular and …, 2019 - Elsevier
Purpose To investigate the feasibility of single-needle high-frequency irreversible
electroporation (SN-HFIRE) to create reproducible tissue ablations in an in vivo pancreatic …

A theoretical argument for extended interpulse delays in therapeutic high-frequency irreversible electroporation treatments

KN Aycock, Y Zhao, MF Lorenzo… - IEEE Transactions on …, 2021 - ieeexplore.ieee.org
High-frequency irreversible electroporation (H-FIRE) is a tissue ablation modality employing
bursts of electrical pulses in a positive phase–interphase delay (d 1)–negative phase …

Understanding the role of calcium-mediated cell death in high-frequency irreversible electroporation

EM Wasson, N Alinezhadbalalami, RM Brock… - …, 2020 - Elsevier
High-frequency irreversible electroporation (H-FIRE) is an emerging electroporation-based
therapy used to ablate cancerous tissue. Treatment consists of delivering short, bipolar …

Burst and continuous high frequency irreversible electroporation protocols evaluated in a 3D tumor model

MB Sano, CC Fesmire, MR DeWitt… - Physics in Medicine & …, 2018 - iopscience.iop.org
High frequency irreversible electroporation (H-FIRE) is an emerging cancer therapy which
uses bursts of alternating polarity pulses to target and destroy the membranes of cells within …

Methods for delivery of biphasic electrical pulses for non-thermal ablation

RV Davalos, PA Garcia, JH Rossmeisl… - US Patent …, 2022 - Google Patents
2019-10-01 Assigned to VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
reassignment VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. ASSIGNMENT OF …

Devices and methods for high frequency electroporation

IIRE Neal, PA Garcia, RV Davalos… - US Patent …, 2022 - Google Patents
2019-06-10 Assigned to VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
reassignment VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. ASSIGNMENT OF …

Device and methods for delivery of biphasic electrical pulses for non-thermal ablation

IIRE Neal, PA Garcia, RV Davalos… - US Patent …, 2024 - Google Patents
The present invention provides systems, methods, and devices for electroporation-based
therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the …