Pharmacogenomics: driving personalized medicine
Personalized medicine tailors therapies, disease prevention, and health maintenance to the
individual, with pharmacogenomics serving as a key tool to improve outcomes and prevent …
individual, with pharmacogenomics serving as a key tool to improve outcomes and prevent …
Cytochrome P450 structure, function and clinical significance: a review
Background: The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins
that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and …
that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and …
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate
the genetic architecture and biology of heart, lung, blood and sleep disorders, with the …
the genetic architecture and biology of heart, lung, blood and sleep disorders, with the …
Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and …
KE Caudle, K Sangkuhl, M Whirl‐Carrillo… - Clinical and …, 2020 - Wiley Online Library
Translating CYP 2D6 genotype to metabolizer phenotype is not standardized across clinical
laboratories offering pharmacogenetic (PGx) testing and PGx clinical practice guidelines …
laboratories offering pharmacogenetic (PGx) testing and PGx clinical practice guidelines …
Pharmacogenetics guidelines: overview and comparison of the DPWG, CPIC, CPNDS, and RNPGx guidelines
H Abdullah-Koolmees, AM Van Keulen… - Frontiers in …, 2021 - frontiersin.org
Many studies have shown that the efficacy and risk of side effects of drug treatment is
influenced by genetic variants. Evidence based guidelines are essential for implementing …
influenced by genetic variants. Evidence based guidelines are essential for implementing …
Review and consensus on pharmacogenomic testing in psychiatry
The implementation of pharmacogenomic (PGx) testing in psychiatry remains modest, in part
due to divergent perceptions of the quality and completeness of the evidence base and …
due to divergent perceptions of the quality and completeness of the evidence base and …
PharmVar GeneFocus: CYP2D6
C Nofziger, AJ Turner, K Sangkuhl… - Clinical …, 2020 - Wiley Online Library
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …
The clinical pharmacogenetics implementation consortium: 10 years later
In 2009, the Clinical Pharmacogenetics Implementation Consortium (CPIC, www. cpicpgx.
org), a shared project between Pharmacogenomics Knowledge Base (PharmGKB …
org), a shared project between Pharmacogenomics Knowledge Base (PharmGKB …
The gene curation coalition: a global effort to harmonize gene–disease evidence resources
Purpose Several groups and resources provide information that pertains to the validity of
gene–disease relationships used in genomic medicine and research; however, universal …
gene–disease relationships used in genomic medicine and research; however, universal …
Comparison of the guidelines of the clinical pharmacogenetics implementation consortium and the dutch pharmacogenetics working group
PCD Bank, KE Caudle, JJ Swen… - Clinical …, 2018 - Wiley Online Library
Both the Clinical Pharmacogenetics Implementation Consortium (CPIC) and Dutch
Pharmacogenetics Working Group provide therapeutic recommendations for well‐known …
Pharmacogenetics Working Group provide therapeutic recommendations for well‐known …