Transition metal catalysis controlled by hydrogen bonding in the second coordination sphere

JNH Reek, B de Bruin, S Pullen, TJ Mooibroek… - Chemical …, 2022 - ACS Publications
Transition metal catalysis is of utmost importance for the development of sustainable
processes in academia and industry. The activity and selectivity of metal complexes are …

Glycomimetics for the inhibition and modulation of lectins

S Leusmann, P Ménová, E Shanin, A Titz… - Chemical Society …, 2023 - pubs.rsc.org
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

The realm of unconventional noncovalent interactions in proteins: their significance in structure and function

VA Adhav, K Saikrishnan - Acs Omega, 2023 - ACS Publications
Proteins and their assemblies are fundamental for living cells to function. Their complex
three-dimensional architecture and its stability are attributed to the combined effect of …

Site-selective, stereocontrolled glycosylation of minimally protected sugars

Q Li, SM Levi, CC Wagen, AE Wendlandt… - Nature, 2022 - nature.com
The identification of general and efficient methods for the construction of oligosaccharides
stands as one of the great challenges for the field of synthetic chemistry,. Selective …

The role of tryptophan in π interactions in proteins: An experimental approach

J Shao, BP Kuiper, AMWH Thunnissen… - Journal of the …, 2022 - ACS Publications
In proteins, the amino acids Phe, Tyr, and especially Trp are frequently involved in π
interactions such as π–π, cation− π, and CH− π bonds. These interactions are often crucial …

Antibacterial derivatives of marine algae: An overview of pharmacological mechanisms and applications

E Shannon, N Abu-Ghannam - Marine drugs, 2016 - mdpi.com
The marine environment is home to a taxonomically diverse ecosystem. Organisms such as
algae, molluscs, sponges, corals, and tunicates have evolved to survive the high …

Exploiting non-covalent interactions in selective carbohydrate synthesis

CCJ Loh - Nature Reviews Chemistry, 2021 - nature.com
Non-covalent interactions (NCIs) are a vital component of biological bond-forming events,
and have found important applications in multiple branches of chemistry. In recent years, the …

Multifaceted computational modeling in glycoscience

S Perez, O Makshakova - Chemical Reviews, 2022 - ACS Publications
Glycoscience assembles all the scientific disciplines involved in studying various molecules
and macromolecules containing carbohydrates and complex glycans. Such an ensemble …

Secondary forces in protein folding

RW Newberry, RT Raines - ACS chemical biology, 2019 - ACS Publications
A complete inventory of the forces governing protein folding is critical for productive protein
modeling, including structure prediction and de novo design, as well as understanding …

The case for post-predictional modifications in the AlphaFold Protein Structure Database

H Bagdonas, CA Fogarty, E Fadda… - Nature structural & …, 2021 - nature.com
To the editor—AlphaFold2 has arrived to change workflows in structural biology, for good.
However, the algorithm does not account for essential modifications that affect protein …