Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: integration of the glutamate/GABA-glutamine cycle
Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …
Glutamate and dopamine in schizophrenia: An update for the 21st century
O Howes, R McCutcheon… - Journal of …, 2015 - journals.sagepub.com
The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …
Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention
Scientists have long sought to characterize the pathophysiologic basis of schizophrenia and
develop biomarkers that could identify the illness. Extensive postmortem and in vivo …
develop biomarkers that could identify the illness. Extensive postmortem and in vivo …
Energy metabolism and inflammation in brain aging and Alzheimer's disease
The high energy demand of the brain renders it sensitive to changes in energy fuel supply
and mitochondrial function. Deficits in glucose availability and mitochondrial function are …
and mitochondrial function. Deficits in glucose availability and mitochondrial function are …
NMR metabolomics: A look ahead
DS Wishart - Journal of Magnetic Resonance, 2019 - Elsevier
NMR has been used to perform metabolic studies, metabolic profiling and metabolomics in
biofluids and tissues for more than 40 years. This close connection between metabolic …
biofluids and tissues for more than 40 years. This close connection between metabolic …
Glutamate and GABA homeostasis and neurometabolism in major depressive disorder
Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …
Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier
SB Hladky, MA Barrand - Fluids and Barriers of the CNS, 2018 - Springer
This review considers efflux of substances from brain parenchyma quantified as values of
clearances (CL, stated in µL g− 1 min− 1). Total clearance of a substance is the sum of …
clearances (CL, stated in µL g− 1 min− 1). Total clearance of a substance is the sum of …
Sleep function and synaptic homeostasis
This paper reviews a novel hypothesis about the functions of slow wave sleep—the synaptic
homeostasis hypothesis. According to the hypothesis, plastic processes occurring during …
homeostasis hypothesis. According to the hypothesis, plastic processes occurring during …
Energy metabolism of the brain, including the cooperation between astrocytes and neurons, especially in the context of glycogen metabolism
A Falkowska, I Gutowska, M Goschorska… - International journal of …, 2015 - mdpi.com
Glycogen metabolism has important implications for the functioning of the brain, especially
the cooperation between astrocytes and neurons. According to various research data, in a …
the cooperation between astrocytes and neurons. According to various research data, in a …
Updates on mouse models of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disease in the United
States (US). Animal models, specifically mouse models have been developed to better …
States (US). Animal models, specifically mouse models have been developed to better …