Context Despite increasing awareness about the potential impact of financial conflicts of
interest on biomedical research, no comprehensive synthesis of the body of evidence …

Background In people who have had a stroke, upper limb paresis affects many activities of
daily life. Reducing disability is therefore a major aim of rehabilitative interventions. Despite …

READ ALL ABOUT IT! David Spiegelhalter has recently joined the ranks of Isaac Newton,
Charles Darwin and Stephen Hawking by becoming a fellow of the Royal Society …

Objective: To assess whether there is evidence that randomized controlled trials are
systematically beneficial, or harmful, for patients. In other words, is there a “trial effect”? If so …

Background Clinical trials test the efficacy of a treatment in a select patient population. We
examined whether cancer clinical trial patients were similar to nontrial,“real-world” patients …

Background Reporting of pharmaceutical-industry-sponsored randomised clinical trials often
result in biased findings, either due to selective reporting of studies with non-equivalent …

Background Many oncologists believe that patients with cancer who enrol in clinical trials
have better outcomes than those who do not enrol. We aimed to assess the empirical …

Although the treatment of atherosclerotic renal artery stenosis with use of percutaneous
angioplasty, stent placement, and surgical revascularization has gained widespread use …

Background Deprescribing describes the complex process that is required for the safe and
effective cessation of medications that are likely to cause more harm than benefit …

Over the past decades, randomised controlled trials (RCTs) have prevailed over clinical
judgement, case reports, and observational studies and became the gold evidential …