The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT).
Indeed, specific lipids can harm CD8+ T cell (CTL) mitochondrial integrity, leading to …

Abstract Current US Food and Drug Administration-approved chimeric antigen receptor
(CAR) T cells harbor the T cell receptor (TCR)-derived ζ chain as an intracellular activation …

Adoptive T cell therapies rely on the production of T cells with an antigen receptor that
directs their specificity toward tumor-specific antigens. Methods for identifying relevant T cell …

Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been
implicated in T-cell antigen recognition, yet their magnitude, spread, and dynamical …

The role of intracellular calcium ion oscillations in T‐cell physiology is being increasingly
appreciated by studies that describe how unique temporal and spatial calcium ion …

Receptors at the membrane of immune cells are the central players of innate and adaptative
immunity, providing effective defence mechanisms against pathogens or cancer cells. Their …

Components of the evolutionarily conserved developmental planar cell polarity (PCP)
pathway were recently described to play a prominent role in cancer cell dissemination …

T cell activation is initiated upon ligand engagement of the T cell receptor (TCR) and
costimulatory receptors. The CD28 molecule acts as a major costimulatory receptor in …

Here we show that the multifunctionality of Janus particles can be exploited for in vitro T cell
activation. We engineer bifunctional Janus particles on which the spatial distribution of two …

Low antigen sensitivity and a gradual loss of effector functions limit the clinical applicability
of chimeric antigen receptor (CAR)–modified T cells and call for alternative antigen receptor …