The basic conclusions in almost all reports on new drug applications and in all publications
in toxicology are based on statistical methods. However, serious contradictions exist in …

Ecotoxicologists often encounter count and proportion data that are rarely normally
distributed. To meet the assumptions of the linear model, such data are usually transformed …

When you write a book on statistics in toxicology you are sitting on the fence: For statisticians
much is known (or at least not exciting), but a large number of toxicologists will be …

Abstract The US National Toxicology Program recommends the use of the parametric
multiple comparison procedures of Dunnett and Williams for the evaluation of repeated …

Motivated by the inability of the Akaike information criterion to distinguish between statistical
models with inequality constraints on parameters, a series of papers have considered …

The identification of the minimum effective dose is of high importance in the drug
development process. In early stage screening experiments, establishing the minimum …

In (eco-) toxicological hazard characterization, the No Observed Adverse Effect
Concentration or Level (NOAEC or NOAEL) approach is used and often required despite of …

The analysis of transcriptomic experiments with ordered covariates, such as dose-response
data, has become a central topic in bioinformatics, in particular in omics studies …

The work presented in this dissertation is focused on the development of biomarkers in non-
clinical and clinical studies. A biomarker is a characteristic that is objectively measured and …

The work presented in this thesis is focused on dose-response relationships in a broad
sense. The proposed methods can be applied to any experiment with an ordered exposure …