Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Osteocalcin is among the most abundant proteins in bone and is produced exclusively by
osteoblasts. Initially believed to be an inhibitor of bone mineralization, recent studies …

Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-
sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic …

INTRODUCTION Myeloid cells have emerged as key regulators of cancer growth because of
their abundance in the tumor stroma in a broad range of cancers, their association with …

Abstract MicroRNAs (miRNAs), short, highly conserved non-coding RNA, influence gene
expression by sequential mechanisms such as mRNA breakdown or translational …

Osteoblasts, which are bone-forming cells, play pivotal roles in bone modeling and
remodeling. Osteoblast differentiation, also known as osteoblastogenesis, is orchestrated by …

The cellular and mechanistic bases underlying endothelial regeneration of adult large
vessels have proven challenging to study. Using a reproducible in vivo aortic endothelial …

Osteosarcoma remains a leading cause of cancer death in adolescents. Treatment
paradigms and survival rates have not improved in two decades. Driving the lack of …

c-Jun is a major component of the dimeric transcription factor activator protein-1 (AP-1), a
paradigm for transcriptional response to extracellular signaling, whose components are …

In vivo and in vitro studies have demonstrated the positive role that ultrasound can play in
the enhancement of fracture healing or in the reactivation of a failed healing process. We …