Oxidative stress, a cytopathic outcome of excessive generation of ROS and the repression of
antioxidant defense system for ROS elimination, is involved in the pathogenesis of multiple …

Contrary to the long-held view that most humans harbour only identical mitochondrial
genomes, deep resequencing has uncovered unanticipated extreme genetic variation within …

Reproduction involves a wide range of biological processes, including organ formation and
development, neuroendocrine regulation, hormone production, and meiosis and mitosis …

Mitochondria are subject to unique genetic control by both nuclear DNA and their own
genome, mitochondrial DNA (mtDNA), of which each mitochondrion contains multiple …

Although there has been considerable debate about whether paternal mitochondrial DNA
(mtDNA) transmission may coexist with maternal transmission of mtDNA, it is generally …

The oocyte is recognised as the largest cell in mammalian species and other multicellular
organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and …

Inherited mitochondrial DNA (mtDNA) diseases were discovered 30 years ago, and their
characterization has provided a new perspective on the etiology of the common metabolic …

Mitochondria are dynamic bioenergetic organelles whose maintenance requires around
1500 proteins from two genomes. Mutations in either the mitochondrial or nuclear genome …

Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA
(mtDNA) copy number and function decline with age in various tissues. There is increasing …

STUDY QUESTION Which add-ons are safe and effective to be used in ART treatment?
SUMMARY ANSWER Forty-two recommendations were formulated on the use of add-ons in …