Abstract Janus kinase 3 (JAK3) is a promising drug target for the treatment of inflammatory
diseases, autoimmune disorders, organ transplant rejection and various cancers. In the …

p38 mitogen-activated protein (MAP) kinases are the serine/threonine protein kinases,
which play a vital role in cellular responses to external stress signals. p38 MAP kinase …

Alzheimer's Disease (AD) is a neurodegenerative condition characterized by progressive
memory loss and other affected cognitive functions. Pharmacological therapy of AD relies on …

Neuraminidase (NA) plays a crucial role in the replication and transmission of influenza
virus. NA inhibitors have been developed as effective treatments for influenza A and B …

Aromatase inhibitors are the most important targets in treatment of estrogen-dependent
cancers. In order to search for potent steroidal aromatase inhibitors (SAIs) with lower side …

Alzheimer's disease (AD) is a neurodegenerative pathology responsible for 70% of
dementia cases worldwide. Despite its relevance, the few drugs available for the treatment …

B-Raf kinase is an important target in treatment of cancers. In order to design and find potent
B-Raf inhibitors (BRIs), 3D pharmacophore models were created using the Genetic …

Neuronal nitric oxide synthase (nNOS) plays an important role in neurotransmission and
smooth muscle relaxation. Selective inhibition of nNOS over its other isozymes is highly …

ERK2 is a dual specificity protein kinase, part of the Ras/Raf/MEK/ERK signal transduction
cascade. It forms an interesting target for inhibition based on its relationship with cell …

The metabotropic glutamate receptors (mGluRs) are known as both synaptic receptors and
taste receptors. This feature is highly similar to the Property and Flavor theory of Traditional …