The nucleolus is the most prominent structure within the eukaryotic cell nucleus and is the
site where ribosomal RNAs (5.8 S, 18S, and 28S) are transcribed, processed, and …

The mechanisms whereby chromosomal translocations are consistently associated with
specific tumor types are largely unknown. A generally accepted hypothesis is that the …

We have analyzed the spatial organization of large scale chromatin domains in chinese
hamster fibroblast, human lymphoid (IM-9), and marsupial kidney epithelial (PtK) cells by …

Abstract Cis-diammininedichloroplatinum (II)(cisplatin or cis-DDP) is a DNA-damaging agent
that is widely used in cancer chemotherapy. Cisplatin crosslinks DNA and the resulting …

Compartmentalization of the nucleus is now recognized as an important level of regulation
influencing specific nuclear processes. The mechanism of factor organization and the …

In eukaryotic cells, mRNA synthesis is carried out by large, multifunctional complexes that
are also involved in coordinating transcription with other nuclear processes. This survey …

ABSTRACT A number of characteristic properties of intermediate filament (IF) proteins, such
as nucleic acid-binding activity, affinity for histones and structural relatedness to transcription …

TFIIH is a general transcription factor for RNA polymerase II that in addition is involved in
DNA excision repair. TFIIH is composed of eight or nine subunits and we show that at least …

Hepatitis delta virus (HDV) is a human pathogen that can greatly increase the severity of
liver damage caused by an hepatitis B infection. HDV contains a circular, single-stranded …

We used fluorescence in situ hybridization (FISH) to study the positions of human
chromosomes on the mitotic rings of cultured human lymphocytes, MRC-5 fibroblasts, and …