The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs)
were originally characterized as passive reservoirs of circulating IGFs, but they are now …

As plant-derived natural products, saponins have been widely applied for the dietary
modification of metabolic syndrome. However, the underlying mechanisms of their …

Nuclear hormone receptors (NRs) are ligand-binding transcription factors that are widely
targeted therapeutically. Agonist binding triggers NR activation and subsequent degradation …

The nuclear receptor farnesoid-X-receptor (FXR) plays an essential role in bile acid,
glucose, and lipid homeostasis. In the last two decades, several diseases, such as obesity …

Co-repressor proteins, such as SMRT and NCoR, mediate the repressive activity of
unliganded nuclear receptors and other transcription factors. They appear to act as …

Ecdysone receptor (EcR) is the primary regulator of the ecdysteroid signalling pathway, a
critical pathway that directly links to moulting. In addition, EcR also regulates growth …

Nuclear receptors are ligand-activated transcription factors that regulate gene expression of
a variety of key molecular signals involved in liver fibrosis. The primary cellular driver of liver …

Nuclear receptors are important bridges between lipid signaling molecules and transcription
responses. Beside their role in several developmental and physiological processes, many of …

How an organism copes with chemicals is largely determined by the genes and proteins that
collectively function to defend against, detoxify and eliminate chemical stressors. This …

Emerging studies revealed that the Aryl hydrocarbon receptor (AhR), a receptor sensing
environmental contaminants, is executing an immunomodulatory function. However, it is an …