[HTML][HTML] The neurobiology of long COVID

M Monje, A Iwasaki - Neuron, 2022 - cell.com
Persistent neurological and neuropsychiatric symptoms affect a substantial fraction of
people after COVID-19 and represent a major component of the post-acute COVID-19 …

SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …

FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

T Brevini, M Maes, GJ Webb, BV John, CD Fuchs… - Nature, 2023 - nature.com
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-
converting enzyme 2 (ACE2), could represent a new chemoprophylactic approach for …

Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

C Greene, R Connolly, D Brennan, A Laffan… - Nature …, 2024 - nature.com
Vascular disruption has been implicated in coronavirus disease 2019 (COVID-19)
pathogenesis and may predispose to the neurological sequelae associated with long …

Innate immunity: the first line of defense against SARS-CoV-2

MS Diamond, TD Kanneganti - Nature immunology, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …

Mechanisms of SARS-CoV-2 entry into cells

CB Jackson, M Farzan, B Chen, H Choe - Nature reviews Molecular …, 2022 - nature.com
The unprecedented public health and economic impact of the COVID-19 pandemic caused
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …

Stroke genetics informs drug discovery and risk prediction across ancestries

A Mishra, R Malik, T Hachiya, T Jürgenson, S Namba… - Nature, 2022 - nature.com
Previous genome-wide association studies (GWASs) of stroke—the second leading cause of
death worldwide—were conducted predominantly in populations of European ancestry …

[HTML][HTML] TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry

J Baggen, M Jacquemyn, L Persoons, E Vanstreels… - Cell, 2023 - cell.com
SARS-CoV-2 is associated with broad tissue tropism, a characteristic often determined by
the availability of entry receptors on host cells. Here, we show that TMEM106B, a lysosomal …

SARS-CoV-2 variants, vaccines, and host immunity

P Mistry, F Barmania, J Mellet, K Peta… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new beta coronavirus
that emerged at the end of 2019 in the Hubei province of China. SARS-CoV-2 causes …

Dysregulation of brain and choroid plexus cell types in severe COVID-19

AC Yang, F Kern, PM Losada, MR Agam, CA Maat… - Nature, 2021 - nature.com
Although SARS-CoV-2 primarily targets the respiratory system, patients with and survivors of
COVID-19 can suffer neurological symptoms,–. However, an unbiased understanding of the …