Migraine is a chronic, neurological disorder generally manifesting itself in attacks with
severe headache, nausea and an increased reactivity to sensory stimuli. A low migraine …

ContextMultiple pathogenic mechanisms may be involved in generating the migraine
symptom complex, and multimechanism-targeted therapy may confer advantages over …

A migraineur can claim to be an infrequent responder ('non-responder') to an oral triptan
independent of which triptan he or she is presently using. Four trials of an alternative triptan …

The effects of different formulation variables including pressure sensitive adhesive (PSA),
thickness of the matrix, solvent system, inclusion of crystallization inhibitor, loading amount …

The triptans represent a relatively new class of compounds effective in the treatment of
migraine. The safety and tolerability of these drugs have been extensively investigated since …

Functional dyspepsia is a clinical syndrome defined by chronic or recurrent pain or
discomfort in the upper abdomen of unknown origin. Although generally accepted …

This review provides information on the role of serotonin and its receptors in the
pathogenesis of primary headaches and, particularly, migraine headaches. We summarized …

Adhesive Dermally-Applied Microarray (ADAM) is a device for intracutaneous drug
administration consisting of a 3 cm2 disposable array of drug-coated titanium …

Over the years the paradigm of treating early during the migraine attack has become well
established in clinical practice. It is also recommended that the 5-HT1B/1D agonists be …

The triptans (selective serotonin agonists) are becoming the first-line alternatives in the
acute pharmacological treatment of migraine, at least for attacks of moderate-to-severe …