Simple Summary The development of HER2-inhibitors for the treatment of HER2-positive
breast cancer represented a breakthrough in targeted tumor therapy. However, as for other …

The redirection of T lymphocytes against tumor-associated or tumor-specific antigens, using
bispecific antibodies or chimeric antigen receptors (CAR), has shown therapeutic success …

The sub-types of breast cancer such as triple-negative and HER2+ patients have 50%
chances of develo** brain metastasis at stage IV of their cancer progression and have …

Ex vivo tumor tissue cultures, such as organoids or explants, hold promise as a drug
screening platform for functional precision diagnostics. In this project, we have employed …

Background Therapies targeting the human epidermal growth factor 2 (HER2) are effective
against breast cancer and several other malignancies. The HER2 variant 611-p95HER2 is …

The offspring's development can be programmed by a maternal high-fat diet (HFD)
consumption, leading to phenotype modulations. Animal models of human Western diet …