Lipid droplet biogenesis and functions in health and disease

A Zadoorian, X Du, H Yang - Nature Reviews Endocrinology, 2023 - nature.com
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

Lipid droplet biogenesis

TC Walther, J Chung… - Annual review of cell and …, 2017 - annualreviews.org
Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or
membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo …

Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites

A Pol, SP Gross, RG Parton - Journal of Cell Biology, 2014 - rupress.org
Abbreviations used in this paper: ACS, acyl-CoA synthetase; AGPAT, 1-acylglycerol-3-
phosphate O-acyltransferase; CCT, CTP: phosphocholine cytidylyltransferase; CoA …

A conserved family of proteins facilitates nascent lipid droplet budding from the ER

V Choudhary, N Ojha, A Golden, WA Prinz - Journal of Cell Biology, 2015 - rupress.org
Lipid droplets (LDs) are ubiquitous organelles that play central roles in energy and lipid
metabolism (Murphy and Vance, 1999; Murphy, 2001; Martin and Parton, 2006). Neutral …

Lipid droplet-organelle contact sites as hubs for fatty acid metabolism, trafficking, and metabolic channeling

MF Renne, H Hariri - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Cells prepare for fluctuations in nutrient availability by storing energy in the form of neutral
lipids in organelles called Lipid Droplets (LDs). Upon starvation, fatty acids (FAs) released …

Lipid droplets, lipophagy, and beyond

CW Wang - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2016 - Elsevier
Lipids are essential components for life. Their various structural and physical properties
influence diverse cellular processes and, thereby, human health. Lipids are not genetically …

Lipid Droplets and Peroxisomes: Key Players in Cellular Lipid Homeostasis or A Matter of Fat—Store 'em Up or Burn 'em Down

SD Kohlwein, M Veenhuis, IJ van der Klei - Genetics, 2013 - academic.oup.com
Lipid droplets (LDs) and peroxisomes are central players in cellular lipid homeostasis: some
of their main functions are to control the metabolic flux and availability of fatty acids (LDs and …

The life cycle of lipid droplets

HF Hashemi, JM Goodman - Current opinion in cell biology, 2015 - Elsevier
Proteomic studies have revealed many potential functions of cytoplasmic lipid droplets, and
recent activity has confirmed that these bona fide organelles are central not only for lipid …

Accumulation of high-value lipids in single-cell microorganisms: a mechanistic approach and future perspectives

LA Garay, KL Boundy-Mills… - Journal of Agricultural and …, 2014 - ACS Publications
In recent years attention has been focused on the utilization of microorganisms as
alternatives for industrial and nutritional applications. Considerable research has been …

Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis

V Choudhary, O El Atab, G Mizzon, WA Prinz… - Journal of Cell …, 2020 - rupress.org
Lipid droplets (LDs) are fat storage organelles that originate from the endoplasmic reticulum
(ER). Relatively little is known about how sites of LD formation are selected and which …