[HTML][HTML] Mechanisms of SARS-CoV-2 entry into cells
The unprecedented public health and economic impact of the COVID-19 pandemic caused
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …
[HTML][HTML] Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19
Coronavirus disease 2019 is a newly emerging infectious disease currently spreading
across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome …
across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome …
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
D Bestle, MR Heindl, H Limburg… - Life science …, 2020 - life-science-alliance.org
The novel emerged SARS-CoV-2 has rapidly spread around the world causing acute
infection of the respiratory tract (COVID-19) that can result in severe disease and lethality …
infection of the respiratory tract (COVID-19) that can result in severe disease and lethality …
Coronavirus infections and type 2 diabetes—shared pathways with therapeutic implications
DJ Drucker - Endocrine reviews, 2020 - academic.oup.com
Abstract Individuals with diabetes are at increased risk for bacterial, mycotic, parasitic, and
viral infections. The severe acute respiratory syndrome (SARS)-CoV-2 (also referred to as …
viral infections. The severe acute respiratory syndrome (SARS)-CoV-2 (also referred to as …
Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation
BJ Fraser, S Beldar, A Seitova, A Hutchinson… - Nature chemical …, 2022 - nature.com
Abstract Transmembrane protease, serine 2 (TMPRSS2) has been identified as key host cell
factor for viral entry and pathogenesis of SARS-CoV-2. Specifically, TMPRSS2 …
factor for viral entry and pathogenesis of SARS-CoV-2. Specifically, TMPRSS2 …
Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity
M Hoffmann, H Hofmann-Winkler, JC Smith… - …, 2021 - thelancet.com
Background Antivirals are needed to combat the COVID-19 pandemic, which is caused by
SARS-CoV-2. The clinically-proven protease inhibitor Camostat mesylate inhibits SARS …
SARS-CoV-2. The clinically-proven protease inhibitor Camostat mesylate inhibits SARS …
The impact of outdoor air pollution on COVID-19: a review of evidence from in vitro, animal, and human studies
T Bourdrel, I Annesi-Maesano… - European respiratory …, 2021 - Eur Respiratory Soc
Studies have pointed out that air pollution may be a contributing factor to the coronavirus
disease 2019 (COVID-19) pandemic. However, the specific links between air pollution and …
disease 2019 (COVID-19) pandemic. However, the specific links between air pollution and …
Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells
H Kimura, D Francisco, M Conway, FD Martinez… - Journal of Allergy and …, 2020 - Elsevier
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
dramatically changed our world, country, communities, and families. There is controversy …
dramatically changed our world, country, communities, and families. There is controversy …
Expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in human primary conjunctival and pterygium cell lines and in mouse cornea
D Ma, CB Chen, V Jhanji, C Xu, XL Yuan, JJ Liang… - Eye, 2020 - nature.com
Purpose To determine the expressions of SARS-CoV-2 receptor angiotensin-converting
enzyme 2 (ACE2) and type II transmembrane serine protease (TMPRSS2) genes in human …
enzyme 2 (ACE2) and type II transmembrane serine protease (TMPRSS2) genes in human …
ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs
IT Lee, T Nakayama, CT Wu, Y Goltsev, S Jiang… - Nature …, 2020 - nature.com
The coronavirus SARS-CoV-2 is the causative agent of the ongoing severe acute respiratory
disease pandemic COVID-19. Tissue and cellular tropism is one key to understanding the …
disease pandemic COVID-19. Tissue and cellular tropism is one key to understanding the …