Soft connective tissues at steady state are dynamic; resident cells continually read
environmental cues and respond to them to promote homeostasis, including maintenance of …

Hypertension is both a cause and a consequence of central artery stiffening, which in turn is
an initiator and indicator of myriad disease conditions and thus all-cause mortality. Such …

The embryonic lineage of intramural cells, microstructural organization of the extracellular
matrix, local luminal and wall geometry, and haemodynamic loads vary along the length of …

The primary function of central arteries is to store elastic energy during systole and to use it
to sustain blood flow during diastole. Arterial stiffening compromises this normal mechanical …

Thoracic aortic aneurysms are life-threatening lesions that afflict young and old individuals
alike. They frequently associate with genetic mutations and are characterized by reduced …

Central artery stiffness has emerged over the past 15 years as a clinically significant
indicator of cardiovascular function and initiator of disease. Loss of elastic fiber integrity is …

Many vascular disorders, including aortic aneurysms and dissections, are characterized by
localized changes in wall composition and structure. Notwithstanding the importance of …

Thoracic aortopathy, especially aneurysm, dissection, and rupture, is responsible for
significant morbidity and mortality. Uncontrolled hypertension and aging are primary risk …

Vascular mechanics has been studied in depth since the early 1970s mainly following
classical concepts from continuum mechanics. Yet, an important distinction of blood vessels …

Considerable insight into effectors of cardiovascular function can be gleaned from controlled
studies on mice, especially given the diverse models that are available. Toward this end …