Extracellular vesicles such as exosomes are now recognized as key players in intercellular
communication. Their role is influenced by the specific repertoires of proteins and lipids …

Neurodegenerative diseases are characterized by progressive dysfunction and loss of
specific sets of neurons. While extensive research has focused on elucidating the genetic …

Alzheimer's disease (AD) is characterised by age-related cognitive decline. Brain
accumulation of amyloid-β plaques and tau tangles is required for a neuropathological AD …

Cells release extracellular vesicles (EVs) of different sizes. Small EVs (< 200 nm) can
originate from the fusion of multivesicular bodies with the plasma membrane, ie exosomes …

Recent studies have identified a family of rod-shaped proteins which includes VPS13 and
ATG2 and are thought to mediate unidirectional lipid transport at intracellular membrane …

The lungs are organs exposed to the external environment, and the air we inhale contains
various pathogens, such as endotoxins. The vagus nerve, which innervates the lungs, may …

The Leucine-rich repeat kinase 2 (LRRK2) not only plays a vital role in familial forms of
Parkinson's disease (PD) but is also considered as a risk factor for idiopathic PD. For these …

Late endosomal secretion is an unconventional mechanism that relies on VAMP7 and is
upregulated in autophagy-null cells. Transcriptomic analysis of VAMP7 knockout cells …