Hypertension is a disease associated with epigenetic aging. However, the pathogenic
mechanism underlying this relationship remains unclear. We aimed to characterize the …

The bidirectional communication network between the gut and the brain, known as the gut–
brain axis, plays a crucial role in health and disease. This review explores the mechanisms …

Schizophrenia is a chronic psychiatric disorder characterized by a variety of symptoms
broadly categorized into positive, negative, and cognitive domains. Its etiology is …

Background Irritable bowel syndrome (IBS) is one of the most common functional
gastrointestinal disorder. Traditionally, early life stress (ELS) is predisposed to IBS in adult …

Advancements in single-cell multimodal techniques have greatly enhanced our
understanding of disease-relevant loci identified through genome-wide association studies …

Studies suggest links between diabetes and gastrointestinal (GI) traits; however, their
underlying biological mechanisms remain unclear. Here, we comprehensively assess the …

Digestive and psychiatric disorders tend to co-occur, yet mechanisms remain unclear.
Leveraging genetic and transcriptomic data integration, we conduct multi-trait analysis of …

Abstract Background and Hypothesis The gut-brain axis plays important roles in both
gastrointestinal diseases (GI diseases) and schizophrenia (SCZ). Moreover, both GI …

Abstract Background and Aim Irritable bowel syndrome (IBS) is a common gastrointestinal
disorder with roots in genetic, immune, psychological, and dietary factors. Recently, the …

Ethnopharmacological relevance Dajianzhong decoction (DJZ) is a classical famous
formula for treating yang-deficiency-syndrome in traditional Chinese medicine and recorded …