Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

The Hippo signaling pathway is a central growth control mechanism in multicellular
organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo …

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …

A growing body of evidence suggests that mechanical signals emanating from the cell's
microenvironment are fundamental regulators of cell behaviour. Moreover, at the …

The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue
homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss …

Studies over the past 20 years have defined the Hippo signaling pathway as a major
regulator of tissue growth and organ size. Diverse roles for the Hippo pathway have …

The first animals evolved from an unknown single-celled ancestor in the Precambrian
period. Recently, the identification and characterization of the genomic and cellular traits of …

The Hippo pathway plays an important role in regulating tissue homeostasis, and its
effectors, the transcriptional co-activators Yes-associated protein (YAP) and WW domain …

How animals evolved from a single-celled ancestor, transitioning from a unicellular lifestyle
to a coordinated multicellular entity, remains a fascinating question. Key events in this …

Choanoflagellates, the closest living relatives of animals, can provide unique insights into
the changes in gene content that preceded the origin of animals. However, only two …