Flavoprotein monooxygenases, a diverse class of oxidative biocatalysts

WJH Van Berkel, NM Kamerbeek, MW Fraaije - Journal of biotechnology, 2006 - Elsevier
During the last decades a large number of flavin-dependent monooxygenases have been
isolated and studied. This has revealed that flavoprotein monooxygenases are able to …

Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork

C Hertweck, A Luzhetskyy, Y Rebets… - Natural product …, 2007 - pubs.rsc.org
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork Page 1
REVIEW www.rsc.org/npr | Natural Product Reports Type II polyketide synthases: gaining a …

The phenazine pyocyanin is a terminal signalling factor in the quorum sensing network of Pseudomonas aeruginosa

LEP Dietrich, A Price‐Whelan, A Petersen… - Molecular …, 2006 - Wiley Online Library
Certain members of the fluorescent pseudomonads produce and secrete phenazines. These
heterocyclic, redox‐active compounds are toxic to competing organisms, and the cause of …

Genomes to natural products prediction informatics for secondary metabolomes (PRISM)

MA Skinnider, CA Dejong, PN Rees… - Nucleic acids …, 2015 - academic.oup.com
Microbial natural products are an invaluable source of evolved bioactive small molecules
and pharmaceutical agents. Next-generation and metagenomic sequencing indicates …

Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides

SJ Gagne, JM Stout, E Liu, Z Boubakir… - Proceedings of the …, 2012 - National Acad Sciences
Δ9-Tetrahydrocannabinol (THC) and other cannabinoids are responsible for the
psychoactive and medicinal properties of Cannabis sativa L.(marijuana). The first …

The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing‐regulated genes are …

E Déziel, S Gopalan, AP Tampakaki… - Molecular …, 2005 - Wiley Online Library
The transcriptional regulator MvfR is required for full Pseudomonas aeruginosa virulence,
the function of multiple quorum sensing (QS)‐regulated virulence factors and the synthesis …

Recent developments in understanding the iron acquisition strategies of gram positive pathogens

JR Sheldon, DE Heinrichs - FEMS microbiology reviews, 2015 - academic.oup.com
Iron is a versatile redox-active catalyst and a required cofactor within a diverse array of
biological processes. To almost all organisms, iron is both essential and potentially toxic …

[HTML][HTML] Gates of enzymes

A Gora, J Brezovsky, J Damborsky - Chemical reviews, 2013 - ACS Publications
Enzymes are very efficient catalysts that are essential for the functioning of living organisms.
The low efficiency of biocatalysts produced de novo relative to those that have evolved …

Biosynthesis of aromatic polyketides in microorganisms using type II polyketide synthases

J Wang, R Zhang, X Chen, X Sun, Y Yan, X Shen… - Microbial cell …, 2020 - Springer
Aromatic polyketides have attractive biological activities and pharmacological properties.
Different from other polyketides, aromatic polyketides are characterized by their polycyclic …

IsdG and IsdI, heme-degrading enzymes in the cytoplasm of Staphylococcus aureus

EP Skaar, AH Gaspar, O Schneewind - Journal of Biological Chemistry, 2004 - ASBMB
Staphylococcus aureus requires iron for growth and utilizes heme as a source of iron during
infection. Staphylococcal surface proteins capture hemoglobin, release heme from …