Molecular Targets of Herbicides and Fungicides─ Are There Useful Overlaps for Fungicide Discovery?
New fungicide modes of action are needed for fungicide resistance management strategies.
Several commercial herbicide targets found in fungi that are not utilized by commercial …
Several commercial herbicide targets found in fungi that are not utilized by commercial …
New quinoxaline compounds as DPP-4 inhibitors and hypoglycemics: design, synthesis, computational and bio-distribution studies
YM Syam, MM Anwar, SS Abd El-Karim, SA Elseginy… - RSC …, 2021 - pubs.rsc.org
The current work represents the design and synthetic approaches of a new set of
compounds 6–10 bearing the 1, 4-dimethyl-2, 3-dioxo-1, 2, 3, 4-tetrahydroquinoxaline-6 …
compounds 6–10 bearing the 1, 4-dimethyl-2, 3-dioxo-1, 2, 3, 4-tetrahydroquinoxaline-6 …
Novel thiobarbiturates as potent urease inhibitors with potential antibacterial activity: Design, synthesis, radiolabeling and biodistribution study
Urease enzyme is a virulence factor that helps in colonization and maintenance of highly
pathogenic bacteria in human. Hence, the inhibition of urease enzymes is well-established …
pathogenic bacteria in human. Hence, the inhibition of urease enzymes is well-established …
Sonophoresis-assisted transdermal delivery of antimigraine-loaded nanolipomers: Radio-tracking, histopathological assessment and in-vivo biodistribution study
Migraine is a disabling neurovascular polygenic disorder affecting life quality with escorted
socioeconomic encumbrances. Herein, we investigated the consolidated amalgamation of …
socioeconomic encumbrances. Herein, we investigated the consolidated amalgamation of …
New cyano-acrylamide derivatives incorporating the thiophene moiety: Synthesis, anti-cancer, gene expression, DNA fragmentation, DNA damage, and in silico …
FM Sroor, HKA Elhakim, SM Abdelrehim… - Journal of Molecular …, 2025 - Elsevier
New cyano-acrylamide derivatives bearing the thiophene moiety were prepared and
rigorously characterized. Thus, the reaction of diethyl 5-(2-cyanoacetamido)-3 …
rigorously characterized. Thus, the reaction of diethyl 5-(2-cyanoacetamido)-3 …
Brain targeting of zolmitriptan via transdermal terpesomes: statistical optimization and in vivo biodistribution study by 99mTc radiolabeling technique
Zolmitriptan (ZT) is a potent second generation triptan, commonly administered to alleviate
migraine attacks. ZT suffers various limitations; massive hepatic first pass metabolism, P-gp …
migraine attacks. ZT suffers various limitations; massive hepatic first pass metabolism, P-gp …
Computational, in vitro and radiation-based in vivo studies on acetamide quinazolinone derivatives as new proposed purine nucleoside phosphorylase inhibitors for …
The present work describes a quinazolinone-based lead optimization for the development of
novel purine nucleoside phosphorylase (PNP) inhibitors with quinazolinone scaffold …
novel purine nucleoside phosphorylase (PNP) inhibitors with quinazolinone scaffold …
In Silico Docking, Resistance Modulation and Biofilm Gene Expression in Multidrug-Resistant Acinetobacter baumannii via Cinnamic and Gallic Acids
Despite the mounting global burden of antimicrobial resistance (AMR), the generation of
new classes of effective antimicrobials still lags far behind. The interplay between multidrug …
new classes of effective antimicrobials still lags far behind. The interplay between multidrug …
Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme
In this study, we have designed and synthesized 2-((5-acetyl-1-(phenyl)-4-methyl-1H-
imidazol-2-yl) thio)-N-(4-((benzyl) oxy) phenyl) acetamide derivatives. Antimicrobial activities …
imidazol-2-yl) thio)-N-(4-((benzyl) oxy) phenyl) acetamide derivatives. Antimicrobial activities …
Antimicrobial and Molecular Docking Studies of 1,3,4-Thiadiazole Tethered Sulfa-Azo Derivatives via Hydrazono-Methyl Bridge
MS Abdel-Aziz, AA Sediek… - Polycyclic Aromatic …, 2025 - Taylor & Francis
Abstract A new series of 1, 3, 4-thiadiazole linked to sulfa-azo derivatives via hydrazono-
methyl bridge were synthesized via the reaction of methyl ((E)-(sulfa-derivatives) diazenyl) …
methyl bridge were synthesized via the reaction of methyl ((E)-(sulfa-derivatives) diazenyl) …