Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …

Schizophrenia (SZ) is a mental disorder that typically emerges in late adolescence or early
adulthood. It reduces the life expectancy of patients by 15 years. Abnormal behavior …

Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a
subset of people with schizophrenia, with significant increases in inflammatory markers …

Background Several studies have trialled anodal transcranial direct current stimulation (a-
tDCS) for the enhancement of working memory (WM) in both healthy and neuropsychiatric …

Importance Prior studies have demonstrated reduced dendritic spine density in the
dorsolateral prefrontal cortex (DLPFC) in schizophrenia. However, it remains unclear how …

Published reports of functional abnormalities in schizophrenia remain divergent due to lack
of staging point-of-view and whole-brain analysis. To identify key functional-connectivity …

For effective information processing, two large-scale distributed neural networks appear to
be critical: a multimodal executive system anchored on the dorsolateral prefrontal cortex …

Cognitive impairment is a feature of many psychiatric diseases, including schizophrenia.
Here we aim to identify multimodal biomarkers for quantifying and predicting cognitive …

The brain is a predictive machine. Converging data suggests a diametric predictive strategy
from autism spectrum disorders (ASD) to schizophrenic spectrum disorders (SSD). Whereas …

Expertly collected, well-curated data sets consisting of comprehensive clinical
characterization and raw structural, functional and diffusion-weighted DICOM images in …