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Interactions between the immune and nervous systems in pain
K Ren, R Dubner - Nature medicine, 2010 - nature.com
Immune cells and glia interact with neurons to alter pain sensitivity and to mediate the
transition from acute to chronic pain. In response to injury, resident immune cells are …
transition from acute to chronic pain. In response to injury, resident immune cells are …
Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors
Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …
Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis
Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic
itch diseases are thought to be driven by both the nervous and immune systems, but the …
itch diseases are thought to be driven by both the nervous and immune systems, but the …
Vanillic acid inhibits inflammatory pain by inhibiting neutrophil recruitment, oxidative stress, cytokine production, and NFκB activation in mice
Vanillic acid (1) is a flavoring agent found in edible plants and fruits. It is an oxidized form of
vanillin. Phenolic compounds form a substantial part of plant foods used as antioxidants with …
vanillin. Phenolic compounds form a substantial part of plant foods used as antioxidants with …
Targeting nitric oxide as a key modulator of sepsis, arthritis and pain
Nitric oxide (NO) is produced by enzymatic activity of neuronal (nNOS), endothelial (eNOS),
and inducible nitric oxide synthase (iNOS) and modulates a broad spectrum of physiological …
and inducible nitric oxide synthase (iNOS) and modulates a broad spectrum of physiological …
Naringenin reduces inflammatory pain in mice
Naringenin is a flavonoid widely consumed by humans that present anti-inflammatory
activity and low toxicity. Recently, the analgesic effect of naringenin has been demonstrated …
activity and low toxicity. Recently, the analgesic effect of naringenin has been demonstrated …
The role of neutrophils in neuro-immune modulation
Neutrophils are peripheral immune cells that represent the first recruited innate immune
defense against infections and tissue injury. However, these cells can also induce …
defense against infections and tissue injury. However, these cells can also induce …
IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy
Abstract Objectives Interleukin 33 (IL-33) is a new member of the IL-1 family of cytokines
which signals via its receptor, ST2 (IL-33R), and has an important role in Th2 and mast cell …
which signals via its receptor, ST2 (IL-33R), and has an important role in Th2 and mast cell …
P2X4 receptors mediate PGE2 release by tissue‐resident macrophages and initiate inflammatory pain
L Ulmann, H Hirbec, F Rassendren - The EMBO journal, 2010 - embopress.org
Prostaglandin E2 (PGE2) is a key mediator of inflammation and contributes to pain
hypersensitivity by promoting sensory neurons hyperexcitability. PGE2 synthesis results …
hypersensitivity by promoting sensory neurons hyperexcitability. PGE2 synthesis results …
IL-17 mediates articular hypernociception in antigen-induced arthritis in mice
IL-17 is an important cytokine in the physiopathology of rheumatoid arthritis (RA). However,
its participation in the genesis of nociception during RA remains undetermined. In this study …
its participation in the genesis of nociception during RA remains undetermined. In this study …