Lung cancer is one of the most common cancer in the world. In 2018, there were over 2
million new cases of lung cancer and over 1.7 million deaths were attributed to lung cancer …

MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and
stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such …

Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …

All patients with metastatic lung, colorectal, pancreatic or head and neck cancers who
initially benefit from epidermal growth factor receptor (EGFR)-targeted therapies eventually …

Lung cancer is the most devastating malignancy in the world. Beyond genetic research,
epigenomic studies—especially investigations of microRNAs—have grown rapidly in …

Antiangiogenic therapy resistance occurs frequently in patients with metastatic renal cell
carcinoma (RCC). The purpose of this study was to understand the mechanism of resistance …

Circular RNAs (circRNAs), one type of non-coding RNA, were initially misinterpreted as
nonfunctional products of pre-mRNA mis-splicing. Currently, circRNAs have been proven to …

Tumor exosomes educate selected host tissues toward a prometastatic phenotype. We
demonstrated this for exosomes of the metastatic rat adenocarcinoma BSp73ASML (ASML) …

Aims Recently, cancer-derived exosomes were shown to have pro-metastasis function in
cancer, but the mechanism remains unclear. Angiogenesis is essential for tumor …

Activating mutations in the epidermal growth factor receptor gene occur as early cancer-
driving clonal events in a subset of patients with non-small cell lung cancer (NSCLC) and …