Stimuli-responsive In situ gelling system for nose-to-brain drug delivery
The diagnosis and treatment of neurological ailments always remain an utmost challenge for
research fraternity due to the presence of BBB. The intranasal route appeared as an …
research fraternity due to the presence of BBB. The intranasal route appeared as an …
Mucosal applications of poloxamer 407-based hydrogels: An overview
Poloxamer 407, also known by the trademark Pluronic® F127, is a water-soluble, non-ionic
triblock copolymer that is made up of a hydrophobic residue of polyoxypropylene (POP) …
triblock copolymer that is made up of a hydrophobic residue of polyoxypropylene (POP) …
Recent advances in the development of in situ gelling drug delivery systems for non-parenteral administration routes
In situ gelling drug delivery systems have gained enormous attention over the last decade.
They are in a sol-state before administration, and they are capable of forming gels in …
They are in a sol-state before administration, and they are capable of forming gels in …
Polymeric in situ forming depots for long-acting drug delivery systems
Polymeric in situ forming depots have emerged as highly promising drug delivery systems
for long-acting applications. Their effectiveness is attributed to essential characteristics such …
for long-acting applications. Their effectiveness is attributed to essential characteristics such …
[HTML][HTML] Ionotropic gelation and chemical crosslinking as methods for fabrication of modified-release gellan gum-based drug delivery systems
Hydrogels have a tridimensional structure. They have the ability to absorb a significant
amount of water or other natural or simulated fluids that cause their swelling albeit without …
amount of water or other natural or simulated fluids that cause their swelling albeit without …
Thermosensitive hydrogels and advances in their application in disease therapy
R Fan, Y Cheng, R Wang, T Zhang, H Zhang, J Li… - Polymers, 2022 - mdpi.com
Thermosensitive hydrogels, having unique sol–gel transition properties, have recently
received special research attention. These hydrogels exhibit a phase transition near body …
received special research attention. These hydrogels exhibit a phase transition near body …
[HTML][HTML] Injectable thermoresponsive hydrogels as drug delivery system for the treatment of central nervous system disorders: A review
The central nervous system (CNS), consisting of the brain, spinal cord, and retina,
superintends to the acquisition, integration and processing of peripheral information to …
superintends to the acquisition, integration and processing of peripheral information to …
[HTML][HTML] Intranasal delivery of Clozapine using nanoemulsion-based in-situ gels: An approach for bioavailability enhancement
Limited solubility and hepatic first-pass metabolism are the main causes of low
bioavailability of anti-schizophrenic drug, Clozapine (CZP). The objective of the study was to …
bioavailability of anti-schizophrenic drug, Clozapine (CZP). The objective of the study was to …
Nanogels as drug carriers–Introduction, chemical aspects, release mechanisms and potential applications
S Shah, N Rangaraj, K Laxmikeshav… - International Journal of …, 2020 - Elsevier
Nanogels, also known as next generation drug delivery systems are in the limelight of the
research owing to their advantages like high loading, tunability of size, stimuli …
research owing to their advantages like high loading, tunability of size, stimuli …
Recent progress in nanocarriers for direct nose to brain drug delivery
Nose to brain drug delivery is considered as a viable option to deliver various therapeutic
agents with low cerebral bioavailability bypass blood-brain barrier (BBB). The drug …
agents with low cerebral bioavailability bypass blood-brain barrier (BBB). The drug …