The severity of human infection by one of the many Shiga toxin-producing Escherichia coli
(STEC) is determined by a number of factors: the bacterial genome, the capacity of human …

Escherichia coli is a remarkable and diverse organism. This normally harmless commensal
needs only to acquire a combination of mobile genetic elements to become a highly adapted …

Successful establishment of infection by bacterial pathogens requires adhesion to host cells,
colonization of tissues, and in certain cases, cellular invasion—followed by intracellular …

Enteric Escherichia coli (E. coli) are both natural flora of humans and important pathogens
causing significant morbidity and mortality worldwide. Traditionally enteric E. coli have been …

Type III secretion systems (T3SSs) are complex bacterial structures that provide gram-
negative pathogens with a unique virulence mechanism enabling them to inject bacterial …

Infections with many Gram-negative pathogens, including Escherichia coli, Salmonella,
Shigella, and Yersinia, rely on type III secretion system (T3SS) effectors. We hypothesized …

The human pathogens enteropathogenic and enterohemorrhagic Escherichia coli (EPEC
and EHEC) share a unique mechanism of colonization that results from the concerted action …

Bacterial pathogens operate by attacking crucial intracellular pathways in their hosts. These
pathogens usually target more than one intracellular pathway and often interact at several …

Cell death signalling pathways contribute to tissue homeostasis and provide innate
protection from infection. Adaptor proteins such as receptor-interacting serine/threonine …

Successful infection by enteric bacterial pathogens depends on the ability of the bacteria to
colonize the gut, replicate in host tissues and disseminate to other hosts. Pathogens such as …