Recent advances in genetics, molecular biology, and stem cell biology have accelerated our
understanding of neuropsychiatric disorders, like autism spectrum disorder (ASD), major …

Bipolar disorder (BD) and schizophrenia are psychiatric disorders that manifest unusual
mental, behavioral, and emotional patterns leading to suffering and disability. These …

Bipolar disorder (BD) is a psychiatric condition characterized by depressive and manic
episodes that affect 2% of the world population. The first-line long-term treatment for mood …

Mutations in the IQSEC2 gene are associated with drug-resistant, multifocal infantile and
childhood epilepsy; autism; and severe intellectual disability (ID). We used induced …

A bstract Bipolar disorder (BD) is a neuropsychiatric illness defined by recurrent episodes of
mania/hypomania, depression and circadian rhythm abnormalities. Lithium is an effective …

N-methyl-D-aspartate receptors (NMDARs) are critical components of the mammalian
central nervous system, involved in synaptic transmission, plasticity, and neurodevelopment …

Autism spectrum disorders (ASDs) are highly heritable and result in abnormal repetitive
behaviors and impairment in communication and cognitive skills. Previous studies have …

Schizophrenia (SCZ) is a complex, heritable and polygenic neuropsychiatric disease, which
disables the patients as well as decreases their life expectancy and quality of life. Common …

Schizophrenia symptomatology includes negative symptoms and cognitive impairment.
Several studies have linked schizophrenia with the PDE4 family of enzymes due to their …

The neurobiological bases of mood instability are poorly understood. Neuronal network
alterations and neurometabolic abnormalities have been implicated in the pathophysiology …