Potent neutralization of SARS-CoV-2 variants by RBD nanoparticle and prefusion-stabilized spike immunogens
We previously described a two-component protein nanoparticle vaccine platform that
displays 60 copies of the SARS-CoV-2 spike protein RBD (RBD-NP). The vaccine, when …
displays 60 copies of the SARS-CoV-2 spike protein RBD (RBD-NP). The vaccine, when …
Establishing RTS, S/AS01 as a benchmark for comparison to next-generation malaria vaccines in a mouse model
E Locke, Y Flores-Garcia, BT Mayer, RS MacGill… - npj Vaccines, 2024 - nature.com
New strategies are needed to reduce the incidence of malaria, and promising approaches
include vaccines targeting the circumsporozoite protein (CSP). To improve upon the malaria …
include vaccines targeting the circumsporozoite protein (CSP). To improve upon the malaria …
Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability
Designing effective monoclonal antibody (mAb) therapeutics faces a multi-parameter
optimization challenge known as “developability”, which reflects an antibody's ability to …
optimization challenge known as “developability”, which reflects an antibody's ability to …
Exploiting human immune repertoire transgenic mice for protective monoclonal antibodies against antimicrobial resistant Acinetobacter baumannii
The use of monoclonal antibodies for the control of drug resistant nosocomial bacteria may
alleviate a reliance on broad spectrum antimicrobials for treatment of infection. We identify …
alleviate a reliance on broad spectrum antimicrobials for treatment of infection. We identify …
How to Accelerate Early Stage of Malaria Vaccine Development by Optimizing Functional Assays
K Miura - Vaccines, 2024 - mdpi.com
While two Plasmodium falciparum circumsporozoite protein-based pre-erythrocytic vaccines
(PEV), RTS, S and R21, have been approved by the WHO, no blood-stage vaccine (BSV) or …
(PEV), RTS, S and R21, have been approved by the WHO, no blood-stage vaccine (BSV) or …
Large-scale antibody immune response map** of splenic B cells and bone marrow plasma cells in a transgenic mouse model
X Pan, SN López Acevedo, C Cuziol… - Frontiers in …, 2023 - frontiersin.org
Molecular characterization of antibody immunity and human antibody discovery is mainly
carried out using peripheral memory B cells, and occasionally plasmablasts, that express B …
carried out using peripheral memory B cells, and occasionally plasmablasts, that express B …
A Transgenic Mouse With a Humanized B-Cell Repertoire Mounts an Antibody Response to Influenza Infection and Vaccination
V Murugaiah, SJ Watson, RF Cunliffe… - The Journal of …, 2024 - academic.oup.com
The development of a universal influenza vaccine likely requires an understanding of
previous exposure to influenza virus (through vaccination or infection) and how that shapes …
previous exposure to influenza virus (through vaccination or infection) and how that shapes …
Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability
Designing effective monoclonal antibody (mAb) therapeutics face a significant challenge
known as" developability", which reflects an antibody's ability to progress through …
known as" developability", which reflects an antibody's ability to progress through …
Cartography of the developability landscapes of native and human-engineered antibodies
Design: ing effective monoclonal antibody (mAb) therapeutics face a significant challenge
known as “developability”, which reflects an antibody's ability to progress through …
known as “developability”, which reflects an antibody's ability to progress through …
Cross-reactive sarbecovirus antibodies induced by mosaic RBD-nanoparticles
Therapeutic monoclonal antibodies (mAbs) against SARS-CoV-2 become obsolete as spike
substitutions reduce antibody binding. To induce antibodies against conserved receptor …
substitutions reduce antibody binding. To induce antibodies against conserved receptor …