Cell therapy: types, regulation, and clinical benefits

AEH El-Kadiry, M Rafei, R Shammaa - Frontiers in Medicine, 2021 - frontiersin.org
Cell therapy practices date back to the 19th century and continue to expand on
investigational and investment grounds. Cell therapy includes stem cell-and non–stem cell …

Trends in mechanobiology guided tissue engineering and tools to study cell-substrate interactions: a brief review

AK Rajendran, D Sankar, S Amirthalingam… - Biomaterials …, 2023 - Springer
Sensing the mechanical properties of the substrates or the matrix by the cells and the
tissues, the subsequent downstream responses at the cellular, nuclear and epigenetic levels …

Advancing tissue decellularized hydrogels for engineering human organoids

BS Moura, MV Monteiro, LP Ferreira… - Advanced Functional …, 2022 - Wiley Online Library
The extracellular matrix plays a critical role in bioinstructing cellular self‐assembly and
spatial (re) configuration processes that culminate in human organoids in vitro generation …

Revealing the clinical potential of high-resolution organoids

J Ko, S Hyung, S Cheong, Y Chung, NL Jeon - Advanced Drug Delivery …, 2024 - Elsevier
The symbiotic interplay of organoid technology and advanced imaging strategies yields
innovative breakthroughs in research and clinical applications. Organoids, intricate three …

Engineered cell culture microenvironments for mechanobiology studies of brain neural cells

L Castillo Ransanz, PFJ Van Altena… - … in Bioengineering and …, 2022 - frontiersin.org
The biomechanical properties of the brain microenvironment, which is composed of different
neural cell types, the extracellular matrix, and blood vessels, are critical for normal brain …

Insights on three dimensional organoid studies for stem cell therapy in regenerative medicine

PE Mulaudzi, H Abrahamse, A Crous - Stem cell reviews and reports, 2024 - Springer
Regenerative medicine has developed as a promising discipline that utilizes stem cells to
address limitations in traditional therapies, using innovative techniques to restore and repair …

Mechanobiology: A landscape for reinterpreting stem cell heterogeneity and regenerative potential in diseased tissues

R Tassinari, E Olivi, C Cavallini, V Taglioli, C Zannini… - Iscience, 2023 - cell.com
Mechanical forces play a fundamental role in cellular dynamics from the molecular level to
the establishment of complex heterogeneity in somatic and stem cells. Here, we highlight the …

Advances and applications of cancer organoids in drug screening and personalized medicine

Y Yang, Y Kong, J Cui, Y Hou, Z Gu, C Ma - Stem Cell Reviews and …, 2024 - Springer
In recent years, the rapid emergence of 3D organoid technology has garnered significant
attention from researchers. These miniature models accurately replicate the structure and …

Hyaluronan modulates the biomechanical properties of the cornea

X Lin, T Mekonnen, S Verma… - … & Visual Science, 2022 - iovs.arvojournals.org
Purpose: Hyaluronan (HA) is a major constituent of the extracellular matrix (ECM) that has
high viscosity and is essential for maintaining tissue hydration. In the cornea, HA is enriched …

[HTML][HTML] Everything you always wanted to know about organoid-based models (and never dared to ask)

I Hautefort, M Poletti, D Papp, T Korcsmaros - Cellular and Molecular …, 2022 - Elsevier
Homeostatic functions of a living tissue, such as the gastrointestinal tract, rely on highly
sophisticated and finely tuned cell-to-cell interactions. These crosstalks evolve and …